ArticleMedicine2018
Postoperative course of Crohn disease according to timing of bowel resection: Results from the CONNECT Study.
Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- EARLY ILEOCECAL RESECTION IN CROHN'S DISEASE: A SYSTEMATIC REVIEW.Arquivos de gastroenterologia · 2026Pooled it
- Meta-analysis of early bowel resection versus initial medical therapy in patient's with ileocolonic Crohn's disease.International journal of colorectal disease · 2020Pooled it
- Exposure to advanced therapies and risk of surgery in Crohn's disease.Surgical endoscopy · 2025Article
- The patient and clinician perspective on 'early' bowel resection for terminal ileal Crohn's disease (EBRIC): protocol for a multicentre mixed-methods study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Clinical Characteristics and Outcomes of Small Bowel Neoplasms in Crohn's Disease: A Case-Control Study.Crohn's & colitis 360 · 2025Article
- Can serious postoperative complications in patients with Crohn's disease be predicted using machine learning?World journal of gastrointestinal surgery · 2024Article
- Primary surgery versus pharmacotherapy for newly diagnosed ileocecal Crohn's disease: a hospital-based cohort study.The Korean journal of internal medicine · 2024Article
- Early Ileocecal Resection for Crohn's Disease Is Associated With Improved Long-term Outcomes Compared With Anti-Tumor Necrosis Factor Therapy: A Population-Based Cohort Study.Gastroenterology · 2023Article
- Impact of timing of primary ileocecal resection on prognosis in patients with Crohn's disease.BJS open · 2023Article
- Kono-S Anastomosis in Crohn's Disease: A Retrospective Study on Postoperative Morbidity and Disease Recurrence in Comparison to the Conventional Side-To-Side Anastomosis.Journal of clinical medicine · 2022Article
- It is not NOD2 - genetic and clinical risk factors for postoperative complications following ileocolic resection in Crohn's disease.International journal of colorectal disease · 2022Article
- Late is too late? Surgical timing and postoperative complications after primary ileocolic resection for Crohn's disease.International journal of colorectal disease · 2022Article
- Surgery for Crohn's disease: upfront or last resort?Gastroenterology report · 2022Review
- The Revival of Surgery in Crohn's Disease-Early Intestinal Resection as a Reasonable Alternative in Localized Ileitis.Biomedicines · 2021Review
- Early Ileocecal Resection Is an Effective Therapy in Isolated Crohn's Disease.Journal of clinical medicine · 2021Article
- Guidelines for the management of patients with Crohn's disease. Recommendations of the Polish Society of Gastroenterology and the Polish National Consultant in Gastroenterology.Przeglad gastroenterologiczny · 2021Article
- [Terminal ileitis in Crohn's disease-Is primary surgery the better treatment?]Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Review
- Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): Crohn's disease.Techniques in coloproctology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that early surgery in Crohn disease (CD) can result in a better clinical course than late surgery. The aim of this study was to compare the clinical course of CD following bowel resection performed at the time of diagnosis (early surgery) and during the course of the disease (late surgery).We reviewed medical records from a hospital-based cohort database that includes Korean CD patients diagnosed before 2009. Patients who underwent bowel resection were included. Age, sex, disease phenotype, time of surgery, medication history including use of corticosteroids, immunomodulators, and biologics, and further surgical history were assessed.In all, 243 CD patients who had undergone bowel resection were included, and 120 patients underwent surgery at the time of diagnosis, while 123 underwent surgery after diagnosis (median 105 months, range 2-277). The use of biologics was significantly higher in the late surgery group than in the early surgery group (P = .020). The use of immunomodulators and reoperation rates did not differ between the groups. Early surgery was associated with less use of biologics (Kaplan-Meier curve analysis P = .015). Multivariate analysis indicated that early surgery and old age at surgery were independent variables associated with less use of biologics.CD patients who underwent bowel resection at the time of diagnosis have a more favorable disease course, represented by less use of biologics. Early surgery might be a treatment option in a subset of CD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.