Evidence map›Paper›PMID 29668401›Full record

Trial reportNeurorehabilitation and neural repair2018

Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 2: Effect on White Matter Integrity.

Ameen Barghi, Jane B Allendorfer, Edward Taub, Brent Womble, Jarrod M Hicks, Gitendra Uswatte, Jerzy P Szaflarski, Victor W Mark

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01081275 (Rehabilitating Extremity Use After Multiple Sclerosis), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01081275 phase2unknown statusnot on this map

Rehabilitating Extremity Use After Multiple Sclerosis

TypeinterventionalSponsorNational Multiple Sclerosis SocietyRan2010 to 2016Enrolled66ConditionsMultiple SclerosisArmsCI Therapy, CAM treatments
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. White Matter Injury in Central Nervous System Disorders.Neuropsychiatric disease and treatment · 2025
    Review
  7. Article
  8. Constraint-induced movement therapy for upper limb rehabilitation in multiple sclerosis.European journal of physical and rehabilitation medicine · 2022
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ameen Barghi1 Harvard Medical School, MA, USA.
Jane B Allendorfer2 University of Alabama at Birmingham, Birmingham, AL, USA.
Edward Taub2 University of Alabama at Birmingham, Birmingham, AL, USA.
Brent Womble2 University of Alabama at Birmingham, Birmingham, AL, USA.
Jarrod M Hicks2 University of Alabama at Birmingham, Birmingham, AL, USA.
Gitendra Uswatte2 University of Alabama at Birmingham, Birmingham, AL, USA.
Jerzy P Szaflarski2 University of Alabama at Birmingham, Birmingham, AL, USA.
Victor W Mark2 University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USHarvard University · US

Funding

Exploring the Effects of Rehabilitation on Brain Remodeling in Progressive MSR21HD061767 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARK, VICTOR WILLIAM · 2009 to 2010
$402k
NICHD NIH HHS R21 HD061767
6 · The paper itself

Abstract

backgroundConstraint-induced movement therapy (CIMT) is a method of physical rehabilitation that has demonstrated clinical efficacy in patients with chronic stroke, cerebral palsy, and multiple sclerosis (MS).

objectiveThis pilot randomized controlled trial tested whether CIMT can also induce increases in white matter integrity in patients with MS.

methodsTwenty adults with chronic hemiparetic MS were randomized to receive either CIMT or complementary and alternative medicine (CAM) treatment (reported in the first article of this pair). Structural white matter change was assessed by tract-based spatial statistics (TBSS); measures included fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD).

resultsCIMT and CAM groups did not differ in pretreatment disability or expectancy to benefit. As noted in the companion paper, the motor activity log (MAL) improved more after CIMT than CAM ( P < .001); the within-group effect size for CIMT was 3.7 (large d' = 0.57), while for CAM it was just 0.7. Improvements in white matter integrity followed CIMT and were observed in the contralateral corpus callosum (FA, P < .05), ipsilateral superior occipital gyrus (AD, P < .05), ipsilateral superior temporal gyrus (FA, P < .05), and contralateral corticospinal tract (MD and RD, P < .05).

conclusionCIMT produced a very large improvement in real-world limb use and induced white matter changes in patients with hemiparetic MS when compared with CAM. The findings suggest in preliminary fashion that the adverse changes in white matter integrity induced by MS might be reversed by CIMT. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (NCT01081275).

Indexed as

AdultDiffusion Tensor ImagingExercise TherapyFemaleHumansMaleMiddle AgedMultiple SclerosisTreatment OutcomeWhite Mattercomplementary and alternative medicineconstraint-induced movement therapymagnetic resonance imagingmultiple sclerosisrehabilitationwhite matter

Identifiers

PMID29668401
PMCPMC5912693
OpenAlexW2801221158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.