Evidence map›Paper›PMID 29668399›Full record

Trial reportNeurorehabilitation and neural repair2018

Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 1: Effects on Real-World Function.

Victor W Mark, Edward Taub, Gitendra Uswatte, David M Morris, Gary R Cutter, Terrie L Adams, Mary H Bowman, Staci McKay

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01081275 (Rehabilitating Extremity Use After Multiple Sclerosis), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01081275 phase2unknown statusnot on this map

Rehabilitating Extremity Use After Multiple Sclerosis

TypeinterventionalSponsorNational Multiple Sclerosis SocietyRan2010 to 2016Enrolled66ConditionsMultiple SclerosisArmsCI Therapy, CAM treatments
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Constraint-induced movement therapy for upper limb rehabilitation in multiple sclerosis.European journal of physical and rehabilitation medicine · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Victor W Mark1 University of Alabama at Birmingham, Birmingham, AL, USA.
Edward Taub1 University of Alabama at Birmingham, Birmingham, AL, USA.
Gitendra Uswatte1 University of Alabama at Birmingham, Birmingham, AL, USA.
David M Morris1 University of Alabama at Birmingham, Birmingham, AL, USA.
Gary R Cutter1 University of Alabama at Birmingham, Birmingham, AL, USA.
Terrie L Adams1 University of Alabama at Birmingham, Birmingham, AL, USA.
Mary H Bowman1 University of Alabama at Birmingham, Birmingham, AL, USA.
Staci McKay1 University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Exploring the Effects of Rehabilitation on Brain Remodeling in Progressive MSR21HD061767 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARK, VICTOR WILLIAM · 2009 to 2010
$402k
NICHD NIH HHS R21 HD061767
6 · The paper itself

Abstract

backgroundConstraint-Induced Movement therapy (CIMT) has controlled evidence of efficacy for improving real-world paretic limb use in non-progressive physically disabling disorders (stroke, cerebral palsy).

objectiveThis study sought to determine whether this therapy can produce comparable results with a progressive disorder such as multiple sclerosis (MS). We conducted a preliminary phase II randomized controlled trial of CIMT versus a program of complementary and alternative medicine (CAM) treatments for persons with MS, to evaluate their effect on real-world disability.

methodsTwenty adults with hemiparetic MS underwent 35 hours of either CIMT or CAM over 10 consecutive weekdays. The primary clinical outcome was change from pretreatment on the Motor Activity Log (MAL).

resultsThe CIMT group improved more on the MAL (2.7 points, 95% confidence interval 2.2-3.2) than did the CAM group (0.5 points, 95% confidence interval -0.1 to 1.1; P < .001). These results did not change at 1-year follow-up, indicating long-term retention of functional benefit for CIMT. The treatments were well tolerated and without adverse events.

conclusionThese results suggest that CIMT can increase real-world use of the more-affected arm in patients with MS for at least 1 year. CLINICAL

trial registrationClinicalTrials.gov NCT01081275.

Indexed as

Activities of Daily LivingAdultExercise TherapyFemaleHumansMaleMiddle AgedMultiple SclerosisTreatment Outcomecomplementary and alternative medicineConstraint-Induced Movement therapymotor activitymultiple sclerosisrehabilitation; disability evaluation

Identifiers

PMID29668399
PMCPMC5978742
OpenAlexW2802478633

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.