ArticleLab on a chip2018
A sharp-edge-based acoustofluidic chemical signal generator.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A Plug-and-Play Volume Minimizing Micromixer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Novel Acoustic Modulation of Oscillating Thin Elastic Membrane for Enhanced Streaming in Microfluidics and Nanoscale Liposome Production.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- [High stability enhanced ultrasonic microfluidic structure with flexible tip coupled bubbles].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator.Microsystems & nanoengineering · 2024Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Microfluidic Continuous Flow DNA Fragmentation based on a Vibrating Sharp-tip.Microfluidics and nanofluidics · 2022Article
- Activation and Switching of Supramolecular Chemical Signals in Multi-Output Microfluidic Devices.Micromachines · 2022Article
- Potential of the acoustic micromanipulation technologies for biomedical research.Biomicrofluidics · 2021Article
- A portable droplet generation system for ultra-wide dynamic range digital PCR based on a vibrating sharp-tip capillary.Biosensors & bioelectronics · 2021Article
- One-step enzyme kinetics measurement in 3D printed microfluidics devices based on a high-performance single vibrating sharp-tip mixer.Analytica chimica acta · 2021Article
- Modeling of Endothelial Calcium Responses within a Microfluidic Generator of Spatio-Temporal ATP and Shear Stress Signals.Micromachines · 2021Article
- Acoustic Streaming Generated by Sharp Edges: The Coupled Influences of Liquid Viscosity and Acoustic Frequency.Micromachines · 2020Article
- Acoustofluidics-Assisted Engineering of Multifunctional Three-Dimensional Zinc Oxide Nanoarrays.ACS nano · 2020Article
- Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics.Lab on a chip · 2020Article
- A Review of Passive Micromixers with a Comparative Analysis.Micromachines · 2020Review
- 3D Printed Multiplexed Competitive Migration Assays with Spatially Programmable Release Sources.Advanced biosystems · 2020Article
- Cell lysis via acoustically oscillating sharp edges.Lab on a chip · 2019Article
- Acoustofluidic Synthesis of Particulate Nanomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Acoustofluidic methods in cell analysis.Trends in analytical chemistry : TRAC · 2019Article
- On-chip stool liquefaction via acoustofluidics.Lab on a chip · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle. We also demonstrate the device's applicability and versatility for cell signaling studies by probing the calcium (Ca2+) release dynamics of three different types of cells stimulated by ionomycin signals of different shapes. Upon short single-pulse ionomycin stimulation (∼100 ms) generated by our device, we discover that cells tend to dynamically adjust the intracellular level of Ca2+ through constantly releasing and accepting Ca2+ to the cytoplasm and from the extracellular environment, respectively. With advantages such as simple fabrication and operation, compact device design, and reliability and versatility, our device will enable decoding of the temporal characteristics of signaling dynamics for various physiological processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.