ArticleAmerican journal of physiology. Renal physiology2018
Experimental heat stress nephropathy and liver injury are improved by allopurinol.
Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- 24 h severe fluid restriction increases a biomarker of renal injury in healthy males.European journal of applied physiology · 2025Trial
- Evaluating the effects of heat strain and air pollution on kidney health.Environment international · 2026Article
- Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney Disease.Antioxidants (Basel, Switzerland) · 2024Review
- Climate change and nephrology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Influence of occupational exposure on hyperuricemia in steelworkers: a nested case-control study.BMC public health · 2022Article
- Chronic scrotal heat stress causes testicular interstitial inflammation and fibrosis: An experimental study in mice.International journal of reproductive biomedicine · 2022Article
- Superoxide Dismutase Prevents SARS-CoV-2-Induced Plasma Cell Apoptosis and Stabilizes Specific Antibody Induction.Oxidative medicine and cellular longevity · 2022Article
- Women and other risk factors for chronic kidney disease of unknown etiology in Thailand: National Health Examination V Survey.Scientific reports · 2021Article
- Selenogenome and AMPK signal insight into the protective effect of dietary selenium on chronic heat stress-induced hepatic metabolic disorder in growing pigs.Journal of animal science and biotechnology · 2021Article
- A Comprehensive Analysis of the Colonic Flora Diversity, Short Chain Fatty Acid Metabolism, Transcripts, and Biochemical Indexes in Heat-Stressed Pigs.Frontiers in immunology · 2021Article
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Detection of heat shock protein 27, 70, 90 expressions in primary parenchymatous organs of goats after transport stress by real-time PCR and ELISA.Veterinary medicine and science · 2020Article
- Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock.Circulation reports · 2020Article
- Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology.International journal of nephrology and renovascular disease · 2020Review
- Mesoamerican Nephropathy (MeN): What We Know so Far.International journal of nephrology and renovascular disease · 2020Review
- Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure.American journal of physiology. Renal physiology · 2019Article
- Review
- Genes and environment in chronic kidney disease hotspots.Current opinion in nephrology and hypertension · 2019Review
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Authors and funding
21 authors at 7 institutions in 5 countries.
Funding
Abstract
An epidemic of chronic kidney disease (CKD) has been observed in Central America among workers in the sugarcane fields. One hypothesis is that the CKD may be caused by recurrent heat stress and dehydration, and potentially by hyperuricemia. Accordingly, we developed a murine model of kidney injury associated with recurrent heat stress. In the current experiment, we tested whether treatment with allopurinol (a xanthine oxidase inhibitor that reduces serum urate) provides renal protection against recurrent heat stress and dehydration. Eight-week-old male C57BL/6 mice were subjected to recurrent heat stress (39.5°C for 30 min, 7 times daily, for 5 wk) with or without allopurinol treatment and were compared with control animals with or without allopurinol treatment. Mice were allowed ad libitum access to normal laboratory chow (Harlan Teklad). Kidney histology, liver histology, and renal function were examined. Heat stress conferred both kidney and liver injury. Kidneys showed loss of proximal tubules, infiltration of monocyte/macrophages, and interstitial collagen deposition, while livers of heat-stressed mice displayed an increase in macrophages, collagen deposition, and myofibroblasts. Allopurinol provided significant protection and improved renal function in the heat-stressed mice. The renal protection was associated with reduction in intrarenal uric acid concentration and heat shock protein 70 expression. Heat stress-induced renal and liver injury can be protected with allopurinol treatment. We recommend a clinical trial of allopurinol for individuals developing renal injury in rural areas of Central America where the epidemic of chronic kidney disease is occurring.
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