Evidence map›Paper›PMID 29667908›Full record

ArticleAmerican journal of physiology. Renal physiology2018

The macula densa prorenin receptor is essential in renin release and blood pressure control.

Anne D M Riquier-Brison, Arnold Sipos, Ágnes Prókai, Sarah L Vargas, Lldikó Toma, Elliott J Meer, Karie G Villanueva, Jennifer C M Chen, Georgina Gyarmati, Christopher Yih and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Role of (pro)renin receptor in cyclosporin A-induced nephropathy.American journal of physiology. Renal physiology · 2022
    Article
  7. Article
  8. A new view of macula densa cell protein synthesis.American journal of physiology. Renal physiology · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. (Pro)renin receptor in the kidney: function and significance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
  14. Review
  15. A new view of macula densa cell microanatomy.American journal of physiology. Renal physiology · 2021
    Article
  16. Article
  17. The (pro)renin receptor in health and disease.Nature reviews. Nephrology · 2019
    Review
  18. Mitochondrial angiotensin receptors and cardioprotective pathways.American journal of physiology. Heart and circulatory physiology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Anne D M Riquier-BrisonDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Arnold SiposDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Ágnes PrókaiDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Sarah L VargasDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Lldikó TomaDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Elliott J MeerDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Karie G VillanuevaDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Jennifer C M ChenDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Georgina GyarmatiDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Christopher YihDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Elaine TangDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Bahram NadimDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Sujith PendekantiDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
Ingrid M GarreldsDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam , The Netherlands.
Genevieve NguyenCentre for Interdisciplinary Research in Biology, UMR INSERM U1050, Collège de France, Paris , France.
A H Jan DanserDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam , The Netherlands.
János Peti-PeterdiDepartments of Physiology and Neuroscience, and Medicine, Zilkha Neurogenetic Institute, University of Southern California , Los Angeles, California.
University of Southern California · USErasmus University Rotterdam · NLInserm · FR

Funding

Multiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4M
Multiphoton microscope replacement for USC shared resourceS10OD021833 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PETI-PETERDI, JANOS · 2017 to 2017
$600k
NIDDK NIH HHS R01 DK064324NIH HHS S10 OD021833
6 · The paper itself

Abstract

The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS); however, recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry-localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE

Indexed as

Blood PressureRenin-Angiotensin SystemAngiotensin-Converting Enzyme InhibitorsAnimalsBiosensing TechniquesCaptoprilCyclooxygenase 2Diet, Sodium-RestrictedDinoprostoneExtracellular Signal-Regulated MAP KinasesHEK293 CellsHumansJuxtaglomerular ApparatusMaleMice, Inbred C57BLMice, KnockoutAngiotensin-Converting Enzyme InhibitorsATP6AP2 protein, humanATP6AP2 protein, mouseCaptoprilCyclooxygenase 2DinoprostoneExtracellular Signal-Regulated MAP KinasesProrenin ReceptorProstaglandin-E SynthasesProton-Translocating ATPasesPtges protein, mousePtgs2 protein, mouseReceptors, Cell SurfaceReninVacuolar Proton-Translocating ATPasesfluorescent reporter micejuxtaglomerular apparatusmacula densaprorenin receptorrenin

Identifiers

PMID29667908
PMCPMC6172576
OpenAlexW2802067112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.