Evidence map›Paper›PMID 29667905›Full record

ReviewModern rheumatology2018

Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament.

Ryo Nakamichi, Kensuke Kataoka, Hiroshi Asahara

Open access · greenAbstract readReview
In one paragraph

Review in Modern rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ryo Nakamichia Department of Systems Biomedicine , Tokyo Medical and Dental University , Tokyo , Japan.
Kensuke Kataokaa Department of Systems Biomedicine , Tokyo Medical and Dental University , Tokyo , Japan.
Hiroshi Asaharaa Department of Systems Biomedicine , Tokyo Medical and Dental University , Tokyo , Japan.
Tokyo Medical and Dental University · JPScripps Research Institute · US

Funding

Transcriptional Regulation of ChondrogenesisR01AR050631 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2004 to 2021
$5.8M
Transcription factor Mohawk in tendon and ligament degeneration and regenerationR01AR065379 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2014 to 2018
$2.1M
The role of microRNAs in chondrogenesis and arthritisR56AR050631 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ASAHARA, HIROSHI · 2009 to 2009
$475k
NIAMS NIH HHS R01 AR050631NIAMS NIH HHS R01 AR065379NIAMS NIH HHS R56 AR050631
6 · The paper itself

Abstract

Tendons and ligaments play essential roles in connecting muscle and bone and stabilizing the connections between bones. The damage to tendons and ligaments caused by aging, injury, and arthritis induces the dysfunction of the musculoskeletal system and reduces the quality of life. Current therapy for damaged tendons and ligaments depends on self-repair; however, it is difficult to reconstruct normal tissue. Regeneration therapy for tendons and ligaments has not been achieved, partly because the mechanism, cell biology, and pathophysiology of tendon and ligament development remain unclear. This review summarizes the role of the transcription factor, Mohawk, which controls tendon and ligament cell differentiation, in the maintenance of cell homeostasis, as well as its function in disease and the possibility of new therapeutic approaches.

Indexed as

AnimalsCell DifferentiationHomeodomain ProteinsHomeostasisHumansIntervertebral DiscPeriodontal LigamentTenocytesHomeodomain ProteinsMKX protein, humandevelopmenthomeostasisregenerationTendon and ligamenttranscription factor

Identifiers

PMID29667905
PMCPMC6511339
OpenAlexW2799378902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.