Evidence map›Paper›PMID 29667853›Full record

ReviewCartilage2019

Evaluation and Management of Subchondral Calcium Phosphate Injection Technique to Treat Bone Marrow Lesion.

Diego Costa Astur, Eduardo Vasconcelos de Freitas, Pedro Barreira Cabral, Caio Carvalho Morais, Bruno Silveira Pavei, Camila Cohen Kaleka, Pedro Debieux, Moises Cohen

Open access · bronzeAbstract readEvaluation StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Safety and early results of Subchondroplasty® for the treatment of bone marrow lesions in osteoarthritis: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
    Pooled it
  3. Surgical treatments of bone marrow lesions.Journal of experimental orthopaedics · 2026
    Review
  4. Article
  5. Combined subchondral and intra-articular injections of bone marrow aspirate concentrate provide stable results up to 24 months.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Percutaneous Skeletal Fixation of Painful Subchondral Bone Marrow Edema of the Knee.Arthroscopy, sports medicine, and rehabilitation · 2020
    Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Diego Costa AsturCentro de Traumatologia do Esporte, Department of Orthopedics and Traumatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Eduardo Vasconcelos de FreitasCohen Institute, São Paulo, SP, Brazil.
Pedro Barreira CabralCohen Institute, São Paulo, SP, Brazil.
Caio Carvalho MoraisCohen Institute, São Paulo, SP, Brazil.
Bruno Silveira PaveiCohen Institute, São Paulo, SP, Brazil.
Camila Cohen KalekaCohen Institute, São Paulo, SP, Brazil.
Pedro DebieuxCohen Institute, São Paulo, SP, Brazil.
Moises CohenCentro de Traumatologia do Esporte, Department of Orthopedics and Traumatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to compile available data in medical literature about subchondral calcium phosphate injection, comparing results obtained with this technique, as well as indications, complications, and other important factors in treatment of bone marrow lesions. DESIGNS: A literature review using PubMed and Medline database in order to identify works with terms "subchondral calcium phosphate injection," " subchondroplasty®," "bone marrow lesion," and "knee." Eight relevant articles were found.

resultsA total of 164 patients with bone marrow lesion mainly on femoral condyle and tibial plateau recovered with significant functional improvement of knee after subchondral calcium phosphate treatment. Although 25% of them still had some type of pain complaint, they also showed improvement. There were few complications reported and return to activities occurred after 3 months on average.

conclusionsFew studies evaluate the result of using subchondral calcium phosphate injection technique. However, all presented favorable results regarding pain and improvement of knee function. In addition, within 2 years, there was a 70% reduction in conversion to total knee arthroplasty in patients with previous surgical indication who choose calcium phosphate treatment.

Indexed as

Bone Marrow DiseasesBone SubstitutesCalcium PhosphatesHumansInjections, Intra-ArticularKnee InjuriesKnee JointRecovery of FunctionBone Substitutescalcium phosphateCalcium Phosphatesbone marrow lesionscartilagesubchondral calcium phosphatesubchondral injurysubchondroplasty

Identifiers

PMID29667853
PMCPMC6755871
OpenAlexW2801666307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.