ArticlePhysics in medicine and biology2018
A random phased-array for MR-guided transcranial ultrasound neuromodulation in non-human primates.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Magnetic Resonance Imaging Monitoring of the Safety of Repeated Low-Intensity Focused Ultrasound Exposure at Three Brain Locations.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- Alternating-contrast single-shot spiral MR-ARFI with model-based displacement map reconstruction.Magnetic resonance in medicine · 2026Article
- A comparative study of experimental and simulated ultrasound beam propagation through cranial bones.Physics in medicine and biology · 2025Article
- Modulating nociception networks: the impact of low-intensity focused ultrasound on thalamocortical connectivity.Brain communications · 2025Article
- Practical Targeting Errors During Optically Tracked Transcranial Focused Ultrasound Using MR-ARFI and Array- Based Steering.IEEE transactions on bio-medical engineering · 2024Article
- Design and Validation of a Patient-Specific Stereotactic Frame for Transcranial Ultrasound Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Reduced-field of view three-dimensional MR acoustic radiation force imaging with a low-rank reconstruction for targeting transcranial focused ultrasound.Magnetic resonance in medicine · 2022Article
- Remus: System for remote deep brain interventions.iScience · 2022Article
- Guiding and monitoring focused ultrasound mediated blood-brain barrier opening in rats using power Doppler imaging and passive acoustic mapping.Scientific reports · 2022Article
- A reduced aperture allows for transcranial focus localization at lower pressure.JASA express letters · 2022Article
- Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans.IEEE transactions on bio-medical engineering · 2021Article
- Review
- Improving the heating efficiency of high intensity focused ultrasound ablation through the use of phase change nanodroplets and multifocus sonication.Physics in medicine and biology · 2020Article
- Neuromodulation Management of Chronic Neuropathic Pain in The Central Nervous system.Advanced functional materials · 2020Article
- A Novel Racing Array Transducer for Noninvasive Ultrasonic Retinal Stimulation: A Simulation Study.Sensors (Basel, Switzerland) · 2019Article
- Article
- Disrupting nociceptive information processing flow through transcranial focused ultrasound neuromodulation of thalamic nuclei.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity. Focus size and grating lobes during electronic steering were quantified using hydrophone measurements in water and a three-axis stage. A novel combination of optical tracking and acoustic mapping enabled measurement of the 3D pressure distribution in the cortical region of an ex vivo skull to within ~3.5 mm of the surface, and allowed accurate modelling of the experiment via non-homogeneous 3D acoustic simulations. The data demonstrates acoustic focusing beyond the skull bone, with the focus slightly broadened and shifted proximal to the skull. The fabricated design is capable of targeting regions within the S1 sensorimotor cortex of macaques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.