ArticleThe Angle orthodontist2018
Growth hormone receptor gene is related to root length and tooth length in human teeth.
Article in The Angle orthodontist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Tracing early life stress in human molar morphology: Associations between linear enamel hypoplasia and maxillary first molar form.PloS one · 2026Article
- Variability in Permanent Teeth Eruption in Children with Growth Hormone Deficiency and Idiopathic Short Stature.Journal of clinical medicine · 2025Article
- Developmental enamel defects and dental anomalies of number and size in children with growth hormone deficiency.Scientific reports · 2023Article
- Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry.PloS one · 2023Article
- New Approach to Dental Morphometric Research Based on 3D Imaging Techniques.Journal of imaging · 2021Article
- Clinical Implications of Growth Hormone Deficiency for Oral Health in Children: A Systematic Review.Journal of clinical medicine · 2021Review
- Review
- Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis.Anatomical science international · 2020Article
- Assessment of Correlation of Growth Hormone Receptor Gene with Tooth Dimensions: A CBCT and Genotyping Study.Journal of pharmacy & bioallied sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the relationship between tooth length and growth hormone receptor (GHR) gene variants in a healthy Japanese population. MATERIALS AND
methodsThe subjects consisted of 193 Japanese adults (69 men, 124 women), aged 13 to 56 years. Genomic DNA was extracted from saliva and genotyped GHR rs6184 and rs6180 variants using the Taqman genotyping. Computed tomography (CT) images were acquired using a dental cone-beam CT scanner and reconstructed using open-source OsiriX medical image processing software. The maxillary (upper; U) and mandibular (lower, L) central incisors (1), lateral incisors (2), canines (3), first premolars (4), second premolars (5), first molars (6), and second premolars (7) were evaluated. Teeth were assessed for crown height (CH), root length (RL), overall tooth length (C+R), and crown to root ratio (C/R). The relationships between GHR variants and CH, RL, C+R, and C/R were statistically examined.
resultsThe GHR variant rs6184 was associated with the root lengths and tooth length for the upper and lower lateral incisors and upper canines (U2 RL; U3 RL, C+R; L2 RL [ P < .05]).
conclusionsThe results indicate that the GHR rs6184 variant is associated with tooth length and ratio dimensions in a Japanese cohort. Further studies utilizing a larger sample size are needed to confirm this finding.
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