Evidence map›Paper›PMID 29667446›Full record

ArticleDrug delivery2018

Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis.

Wenshuai Fan, Jinghuan Li, Liu Yuan, Jifei Chen, Zhe Wang, Yiming Wang, Changan Guo, Xiumei Mo, Zuoqin Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Wenshuai Fana Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Jinghuan Lib Department of Hepatic Oncology , Liver Cancer Institute, Zhongshan Hospital, Fudan University , Shanghai , China.
Liu Yuanc Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
Jifei Chena Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Zhe Wanga Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Yiming Wanga Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Changan Guoa Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Xiumei Moc Biomaterials and Tissue Engineering Lab , College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai , China.
Zuoqin Yana Department of Orthopedics , Zhongshan Hospital, Fudan University , Shanghai , China.
Donghua University · CNSun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common form of joint disease and a leading cause of physical disability, there is an urgent need to attenuate the progression of OA. Intra-articular (IA) injection is an effective treatment for joints diseases, however, the therapeutic effects mostly depend on the efficacy of drug duration in joints. Drug delivery system can provide drug-controlled release and reduce the number of IA injection. In this study, amphiphilic polyurethanes with pendant amino group were synthesized and amide bonds were formed between the amine group of polyurethane and the carboxyl group of kartogenin (KGN), a small molecular reported to show both regenerative and protective effects on cartilage. Our results showed that KGN-conjugated polyurethane nanoparticles (PN-KGN) were spherical and regular in shape with an average size of 25 nm and could sustained and controlled release of KGN in vitro. PN-KGN showed no cytotoxicity and pro-inflammatory effects on chondrocytes. The therapeutic effects in OA model showed that IA injection of KGN could attenuate the progress of OA, however, the cartilage degeneration became obviously at 12 weeks with matrix loss and vertical fissures. By contrast, IA injection of PN-KGN showed less cartilage degeneration with significant lower OARSI scores even at 12 weeks, indicating PN-KGN could further arrest the development of OA. Immunohistochemistry also validated that IA injection of PN-KGN retained the normal compositions of cartilage matrix, with much stronger Col II staining and less Col I staining. In conclusion, IA injection of PN-KGN is a better potential strategy to treat OA, with long-time cartilage protection and less IA injections.

Indexed as

AnilidesAnimalsCartilageChondrocytesDelayed-Action PreparationsInjections, Intra-ArticularMaleNanoparticlesOsteoarthritisPhthalic AcidsPolyurethanesRatsRats, Sprague-DawleyAnilidesDelayed-Action PreparationskartogeninPhthalic AcidsPolyurethanesintra-articular injectionkartogeninOsteoarthritispolyurethane nanoparticles

Identifiers

PMID29667446
PMCPMC6058480
OpenAlexW2800408212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.