ArticleESC heart failure2018
ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end-stage heart failure patients.
Article in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 0 citations in OpenAlex.
- A pilot study on DNA methylation changes for non-invasive molecular diagnostics in heart failure.ESC heart failure · 2025Observational
- Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.Cell death & disease · 2025Article
- ASB1 engages with ELOB to facilitate SQOR ubiquitination and HRedox biology · 2025Article
- Prevalence and Associated Factors of Sensorineural Hearing Impairment Among Patients with T2DM in Amhara Region, Northwest Ethiopia, 2022: A Multi-Centered Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- ASB1 inhibits prostate cancer progression by destabilizing CHCHD3 via K48-linked ubiquitination.American journal of cancer research · 2024Article
- Targeted DNA Demethylation: Vectors, Effectors and Perspectives.Biomedicines · 2023Review
- Epigenome-wide DNA methylation profiling in comparison between pathological and physiological hypertrophy of human cardiomyocytes.Frontiers in genetics · 2023Article
- DNMT3B System Dysregulation Contributes to the Hypomethylated State in Ischaemic Human Hearts.Biomedicines · 2022Article
- Identification of vital modules and genes associated with heart failure based on weighted gene coexpression network analysis.ESC heart failure · 2022Article
- An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.American journal of translational research · 2021Article
- ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end-stage heart failure patients.ESC heart failure · 2018Article
- Epigenome-Wide Analyses Identify Two Novel Associations With Recurrent Stroke in the Vitamin Intervention for Stroke Prevention Clinical Trial.Frontiers in genetics · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIschaemic cardiomyopathy (ICM) leads to impaired contraction and ventricular dysfunction, causing high rates of morbidity and mortality. Epigenomics allows the identification of epigenetic signatures in human diseases. We analyse the differential epigenetic patterns of the ASB gene family in ICM patients and relate these alterations to their haemodynamic and functional status. METHODS AND
resultsEpigenomic analysis was carried out using 16 left ventricular (LV) tissue samples, eight from ICM patients undergoing heart transplantation and eight from control (CNT) subjects without cardiac disease. We increased the sample size up to 13 ICM and 10 CNT for RNA sequencing and to 14 ICM for pyrosequencing analyses. We found a hypermethylated profile (cg11189868) in the ASB1 gene that showed a differential methylation of 0.26Δβ (P = 0.016). This result was validated by a pyrosequencing technique (0.23Δβ, P = 0.048). Notably, the methylation pattern was strongly related to LV ejection fraction (r = -0.849, P = 0.008), stroke volume (r = -0.929, P = 0.001), and end-systolic and diastolic LV diameters (r = -0.743, P = 0.035 for both). ASB1 showed a down-regulation in messenger RNA levels (-1.2-fold, P = 0.039).
conclusionsOur findings link a specific ASB1 methylation pattern to LV structure and performance in end-stage ICM, opening new therapeutic opportunities and providing new insights regarding which is the functionally relevant genome in the ischaemic failing myocardium.
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