Evidence map›Paper›PMID 29667227›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018

Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures.

Dongrim Seol, Yuki Tochigi, Ashley M Bogner, Ino Song, Douglas C Fredericks, Gail L Kurriger, Sonja M Smith, Jessica E Goetz, Joseph A Buckwalter, James A Martin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Posttraumatic osteoarthritis: from basic science to clinical implications.OTA international : the open access journal of orthopaedic trauma · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dongrim SeolDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Yuki TochigiDepartment of Orthopaedic Surgery, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
Ashley M BognerBone Healing Research Laboratory and Iowa Spine Research Laboratory, University of Iowa, Coralville, IA 52241.
Ino SongDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Douglas C FredericksDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Gail L KurrigerDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Sonja M SmithDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Jessica E GoetzDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
Joseph A BuckwalterDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
James A MartinDepartment of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242.
University of Iowa · USDokkyo Medical University Saitama Medical Center · JP

Funding

Tissue and Experimental Modeling CoreP50AR055533 · NIAMS · UNIVERSITY OF IOWA · PI GOETZ, JESSICA E · 2007 to 2016
$14.9M
Iowa Department of Orthopedics and RehabilitationNIAMS NIH HHS P50 AR055533NIH NIAMS
6 · The paper itself

Abstract

Our group employed the mouse closed intra-articular fracture (IAF) model to test the hypothesis that the innate immune system plays a role in initiating synovitis and post-traumatic osteoarthritis (PTOA) in fractured joints. A transgenic strategy featuring knockout of the receptor for advanced glycation end-products (RAGE

Indexed as

Bone DensityAnimalsCartilage, ArticularDisease Models, AnimalIntra-Articular FracturesMaleMatrix Metalloproteinase 13Matrix Metalloproteinase 3MiceMice, Inbred C57BLMice, KnockoutOsteoarthritisReceptor for Advanced Glycation End ProductsSynovitisTibial FracturesX-Ray MicrotomographyAger protein, mouseMatrix Metalloproteinase 13Matrix Metalloproteinase 3Mmp13 protein, mouseMmp3 protein, mouseReceptor for Advanced Glycation End ProductsBMDintra-articular fracturePTOARAGEsynovitis

Identifiers

PMID29667227
PMCPMC6128287
OpenAlexW2804745236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.