Evidence map›Paper›PMID 29667221›Full record

ArticleBritish journal of clinical pharmacology2018

Evident bias in a paracetamol metabolite population pharmacokinetic model applied to an external dataset.

Jessica K Roberts, Matthew W Linakis, Xiaoxi Liu, Catherine M T Sherwin, John N van den Anker

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jessica K RobertsDivision of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Matthew W LinakisDivision of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0526-2395
Xiaoxi LiuDivision of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-1168-6816
Catherine M T SherwinDivision of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-0844-3207
John N van den AnkerDivision of Clinical Pharmacology, Children's National Health System, Washington, DC, USA.

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
Metabolism and Toxicity of Acetaminophen in Preterm InfantsR01HD060543 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VAN DEN ANKER, JOHANNES NICOLAAS · 2010 to 2014
$1.5M
NCATS NIH HHS UL1 TR000075NICHD NIH HHS R01 HD060543
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetaminophenAnalgesics, Non-NarcoticBiasHumansInfant, NewbornAcetaminophenAnalgesics, Non-Narcoticacetaminophenexternal validationneonateNONMEMparacetamolpopulation pharmacokinetics

Identifiers

PMID29667221
PMCPMC6005626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.