Evidence map›Paper›PMID 29667208›Full record

ArticlePacing and clinical electrophysiology : PACE2018

The use of cardiac-CT alone to exclude left atrial thrombus before atrial fibrillation ablation: Efficiency, safety, and cost analysis.

Wassim Mosleh, Ali Sheikh, Zaid Said, Mohamed Abdel-Aal Ahmed, Siri Gadde, Tanvi Shah, Michael F Wilson, Hiroko Beck, Chee Kim, Umesh C Sharma

Abstract read
In one paragraph

Article in Pacing and clinical electrophysiology : PACE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Inpatient cardiac computed tomography angiography in Germany between 2005 and 2023: a nationwide registry study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wassim MoslehDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-3597-0106
Ali SheikhDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Zaid SaidDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Mohamed Abdel-Aal AhmedDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Siri GaddeDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Tanvi ShahDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Michael F WilsonDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Hiroko BeckDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Chee KimDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.
Umesh C SharmaDivision of Cardiology, Department of Medicine, University at Buffalo, Buffalo, NY, USA.

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Institutional Career DevelopmentKL2TR001413 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2015 to 2024
$4.2M
Galectin-3-Mediated Post-Ischemic Myocardial Dysfunction and its Inhibition by a Novel Peptide N-Acetyl-Seryl-Aspartyl-Lysyl-ProlineK08HL131987 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SHARMA, UMESH C · 2017 to 2021
$987k
NCATS NIH HHS KL2 TR001413NCATS NIH HHS UL1 TR001412NHLBI NIH HHS K08 HL131987
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is a growing financial burden on the healthcare system. Cardiac computed tomographic angiography (CCTA) is needed for pulmonary vein mapping before AF ablation (AFA). CCTA has shown to be an alternative to transesophageal echocardiogram (TEE) to rule out left atrial appendage thrombus (LAAT) pre-AFA. We aim to examine the safety, cost-effectiveness, and time-efficiency of utilizing CCTA alone to rule out LAAT before AFA.

methodsWe prospectively screened patients with paroxysmal AF undergoing cryoablation. CCTA with delayed enhancement was performed within 72 hours of AFA. Once LAAT was ruled out, patients were enrolled and planned TEE was cancelled. A retrospective control cohort that had both CCTA and TEE prior to AFA was identified. Direct cost data, electrophysiology laboratory utilization time, and 30-day stroke outcomes were collected from the EMR, follow-up phone calls, or clinic visits, and comparative analyses were performed.

resultsSeventy patients met the inclusion criteria in the prospective CCTA-only cohort, and 71 for the retrospective CCTA+TEE cohort. Baseline characteristics were similar between the two groups. There was a nonsignificant reduction in overall cost ($15,870 ± 1,710 vs $16,557 ± 2,508, P = 0.06) in CCTA-only cohort, whereas the electrophysiology laboratory utilization time was significantly reduced (241.6 ± 41.7 vs 181.3 ±36.4 minutes, P < 0.001). There were no strokes reported on 30-day follow-up in the CCTA-only group.

conclusionsIn low-to-intermediate stroke risk patients with paroxysmal AF undergoing cryoablation, eliminating TEE and employing CCTA-only strategy to rule-out LAAT improves electrophysiology laboratory efficiency without influencing periprocedural cost or increasing postprocedural stroke risk.

Indexed as

Catheter AblationCosts and Cost AnalysisAtrial FibrillationCardiac Imaging TechniquesFemaleHeart AtriaHeart DiseasesHumansMaleMiddle AgedPreoperative CareRetrospective StudiesThrombosisTomography, X-Ray Computedatrial fibrillationCCTAleft atrial thrombustransesophageal echocardiography

Identifiers

PMID29667208
PMCPMC6192873

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.