Evidence map›Paper›PMID 29667127›Full record

ArticleNeurotoxicity research2018

Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABA

Xiaomin Zheng, Liang Liang, Changchun Hei, Wenjuan Yang, Tingyuan Zhang, Kai Wu, Yi Qin, Qing Chang

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaomin ZhengKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, The School of Basic Medicine, Department of Anatomy, Ningxia Medical University, Yinchuan, 750004, China. 972514523@qq.com.
Liang LiangHubei General Hospital, Wuhan, 430060, China.
Changchun HeiKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, The School of Basic Medicine, Department of Anatomy, Ningxia Medical University, Yinchuan, 750004, China.
Wenjuan YangTongxin County Hospital, Tongxin County, Ningxia Hui Autonomous Region, Yinchuan, 751300, China.
Tingyuan ZhangPeople' s Hospital of Heze City, Shandong, 274015, China.
Kai WuKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, The School of Basic Medicine, Department of Anatomy, Ningxia Medical University, Yinchuan, 750004, China.
Yi QinKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, The School of Basic Medicine, Department of Anatomy, Ningxia Medical University, Yinchuan, 750004, China.
Qing ChangKey Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, The School of Basic Medicine, Department of Anatomy, Ningxia Medical University, Yinchuan, 750004, China. 1014562939@qq.com.
Ningxia Medical University · CNHeze Municipal Hospital · CNNingxia Hui Autonomous Region Peoples Hospital · CNRenmin Hospital of Wuhan University · CN

Funding

National Natural Science Foundation of China 30960114National Natural Science Foundation of China 81460644West China First-Class Discipline Construction Project NXYLXK2017B07
6 · The paper itself

Abstract

Chloroform-induced olfactory mucosal degeneration has been reported in adult rats following gavage. We used fixed-point chloroform infusions on different postnatal days (PNDs) to investigate the effects of early olfactory bilateral deprivation on the main olfactory bulbs in Sprague Dawley rats. The experimental groups included rats infused with chloroform (5 μl) or saline (sham, 5 μl) on PNDs 3 and 8, and rats not receiving infusions (control) (n = 6 in all groups). Rats receiving chloroform on PND 3 showed significant hypoevolutism when compared to those in other groups (P < 0.05). There was a complete disappearance and a significant reduction in the size of olfactory glomeruli in the PND 3 and 8 groups, respectively, when compared to the respective sham groups. Rats receiving chloroform on PND 3 had significant memory impairment (P < 0.01) and increased levels of learned helplessness (P < 0.05), as measured using the Morris water maze and tail suspension tests, respectively. GABA

Indexed as

Age FactorsAnalysis of VarianceAnimalsAnimals, NewbornChloroformDepressionFemaleGene Expression Regulation, DevelopmentalHindlimb SuspensionHippocampusMaleMaze LearningOlfaction DisordersOlfactory MucosaOlfactory Receptor NeuronsRatsChloroformGabra5 protein, ratReceptors, GABA-ARNA, MessengerSolventsDevelopmentOlfactory glomerulusOlfactory mucosaSprague Dawleyα5GABAARs

Identifiers

PMID29667127
OpenAlexW2802646995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.