Evidence map›Paper›PMID 29667104›Full record

ArticleCancer causes & control : CCC2018

Fruit and vegetable intake and the risk of recurrence in patients with non-muscle invasive bladder cancer: a prospective cohort study.

Sylvia H J Jochems, Frits H M van Osch, Raoul C Reulen, Mitch van Hensbergen, Duncan Nekeman, Sarah Pirrie, Anke Wesselius, Frederik-Jan van Schooten, Nicholas D James, D Michael A Wallace and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Sylvia H J JochemsInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. s.jochems@maastrichtuniversity.nl.ORCID 0000-0001-7676-1488
Frits H M van OschInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Raoul C ReulenDepartment of Public Health, Epidemiology and Biostatistics, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Mitch van HensbergenDepartment of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Duncan NekemanInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Sarah PirrieInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Anke WesseliusDepartment of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Frederik-Jan van SchootenDepartment of Complex Genetics and Epidemiology, School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Nicholas D JamesInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
D Michael A WallaceInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Richard T BryanInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
K K ChengDepartment of Public Health, Epidemiology and Biostatistics, Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Maurice P ZeegersInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Maastricht University · NLUniversity of Birmingham · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is some evidence that greater consumption of fruit and vegetables decreases the risk of bladder cancer. The role of fruit and vegetables in bladder cancer recurrence is still unknown.

objectiveThe role of total fruit and vegetable intake in relation to the risk of developing bladder cancer recurrence in a prospective cohort study.

methods728 patients with non-muscle invasive bladder cancer (NMIBC), who completed self-administrated questionnaires on fruit and vegetable intake at time of diagnosis (over the year before diagnosis) and 1 year after diagnosis, were included. Hazard ratios and 95% confidence intervals were calculated by multivariable Cox regression for developing recurrent bladder cancer in relation to fruit and vegetable intake.

resultsDuring 2,051 person-years of follow-up [mean (SD) follow-up 3.7 (1.5) years], 241 (33.1%) of the included 728 NMIBC patients developed a recurrence of bladder cancer. The sum of total fruit and vegetables before diagnosis was not related to a first bladder cancer recurrence (HR 1.07; 95% CI 0.78-1.47, p = 0.66). No association was found between greater consumption of fruit and vegetables over the year before diagnosis and the risk of developing multiple recurrences of bladder cancer (HR 1.02; 95% CI 0.90-1.15, p = 0.78). Among the remaining 389 NMIBC patients who reported on fruit and vegetable intake 1 year after diagnosis, no association was found between greater consumption of fruit and vegetables and a first recurrence of bladder cancer (HR 0.65; 95% CI 0.42-1.01, p = 0.06) nor with multiple recurrences of bladder cancer (HR 1.00, 95% CI 0.85-1.18, p = 1.00). Similar results were obtained when investigating the association between total intakes of fruit and vegetables separately and bladder cancer recurrence.

conclusionResults from this study did not indicate a protective role for total fruit and vegetables in the development of a recurrence of NMIBC.

Indexed as

FruitVegetablesAdultAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalProportional Hazards ModelsProspective StudiesSurveys and QuestionnairesUrinary Bladder NeoplasmsBladder cancerFruitPrevention and controlRecurrenceVegetables

Identifiers

PMID29667104
PMCPMC5938309
OpenAlexW2799842135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.