ArticleEuropean radiology2018
Disturbed left and right ventricular kinetic energy in patients with repaired tetralogy of Fallot: pathophysiological insights using 4D-flow MRI.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- End-Diastolic Forward Flow and Restrictive Physiology in Repaired Tetralogy of Fallot: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Four-dimensional flow cardiovascular magnetic resonance in tetralogy of Fallot: a systematic review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Pooled it
- 4D Flow Yields Similar Clinical Results Compared To 2D Phase Contrast for Decision Making Regarding Pulmonary Valve Replacement in Repaired Tetralogy of Fallot.Pediatric cardiology · 2026Article
- Characteristic flow of different right ventricular outflow tract morphology in repaired tetralogy of fallot patients studied by 4D-flow cardiac magnetic resonance images.BMC medical imaging · 2026Article
- End-diastolic forward flow (EDFF) after tetralogy of Fallot repair: Evolution of its role in management and prognosis.International journal of cardiology. Congenital heart disease · 2026Review
- Increased contractility affects left ventricular kinetic energy in pulmonary hypertension.Physiological reports · 2025Observational
- Assessing the Impact of Cardiac Output and Valve Orientation on Bioprosthetic Pulmonary Valve Hemodynamics Using In Vitro 4D-Flow MRI and High-Speed Imaging.Cardiovascular engineering and technology · 2025Article
- Intracardiac fluid dynamic analysis: available techniques and novel clinical applications.BMC cardiovascular disorders · 2024Review
- Diastolic Right Ventricle Dysfunction in Repaired Tetralogy of Fallot: Is it Time for 4D-Flow-MRI Parameters?JACC. Asia · 2024Article
- Right Ventricular Restrictive Physiology Is Associated With Right Ventricular Direct Flow From 4D Flow CMR.JACC. Asia · 2024Article
- Image reconstruction impacts haemodynamic parameters derived from 4D flow magnetic resonance imaging with compressed sensing.European heart journal. Imaging methods and practice · 2024Article
- Characteristics of altered biventricular hemodynamics after arterial switch operation for patients with d-transposition of the great arteries with preserved ejection fraction: a four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) study.Quantitative imaging in medicine and surgery · 2024Article
- Revolutionizing vascular imaging: trends and future directions of 4D flow MRI based on a 20-year bibliometric analysis.Quantitative imaging in medicine and surgery · 2024Article
- Enhanced echocardiographic assessment of intracardiac flow in congenital heart disease.PloS one · 2024Article
- Advanced Imaging Technologies for Assessing Tetralogy of Fallot: Insights Into Flow Dynamics.CJC pediatric and congenital heart disease · 2023Review
- Age- and sex-specific reference values of biventricular flow components and kinetic energy by 4D flow cardiovascular magnetic resonance in healthy subjects.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Observational
- Discordance between 2D and 4D flow in the assessment of pulmonary regurgitation severity: a right ventricular remodeling follow-up study.European radiology · 2023Article
- Effect of Aging on Intraventricular Kinetic Energy and Energy Dissipation.Journal of cardiovascular development and disease · 2023Review
- Patients with volume-loaded right ventricle - quantification of left ventricular hemodynamic response to intervention measured by noninvasive pressure-volume loops.Frontiers in physiology · 2023Article
- Statistical shape modeling reveals the link between right ventricular shape, hemodynamic force, and myocardial function in patients with repaired tetralogy of Fallot.American journal of physiology. Heart and circulatory physiology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIndications for pulmonary valve replacement (PVR) in patients with pulmonary regurgitation (PR) after repaired tetralogy of Fallot (rToF) are debated. We aimed to compare right (RV) and left ventricular (LV) kinetic energy (KE) measured by 4D-flow magnetic resonance imaging (MRI) in patients to controls, to further understand the pathophysiological effects of PR.
methodsFifteen patients with rToF with PR > 20% and 14 controls underwent MRI. Ventricular volumes and KE were quantified from cine MRI and 4D-flow, respectively. Lagrangian coherent structures were used to discriminate KE in the PR. Restrictive RV physiology was defined as end-diastolic forward flow.
resultsLV systolic peak KE was lower in rToF, 2.8 ± 1.1 mJ, compared to healthy volunteers, 4.8 ± 1.1 mJ, p < 0.0001. RV diastolic peak KE was higher in rToF (7.7 ± 4.3 mJ vs 3.1 ± 1.3 mJ, p = 0.0001) and the difference most pronounced in patients with non-restrictive RV physiology. KE was primarily located in the PR volume at the time of diastolic peak KE, 64 ± 17%.
conclusionThis is the first study showing disturbed KE in patients with rToF and PR, in both the RV and LV. The role of KE as a potential early marker of ventricular dysfunction to guide intervention needs to be addressed in future studies. KEY POINTS: • Kinetic energy (KE) reflects ventricular performance • KE is a potential marker of ventricular dysfunction in Fallot patients • KE is disturbed in both ventricles in patients with tetralogy of Fallot • KE contributes to the understanding of the pathophysiology of pulmonary regurgitation • Lagrangian coherent structures enable differentiation of ventricular inflows.
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