Evidence map›Paper›PMID 29666982›Full record

ArticleInflammation2018

ERK1/2 and the Bcl-2 Family Proteins Mcl-1, tBid, and Bim Are Involved in Inhibition of Apoptosis During Persistent Chlamydia psittaci Infection.

Li Li, Chuan Wang, Yating Wen, Yuming Hu, Yafeng Xie, Man Xu, Mingxing Liang, Wei Liu, Liangzhuan Liu, Yimou Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Virulence · 2024
    Review
  5. Review
  6. Microorganisms · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Li LiHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Chuan WangHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Yating WenHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Yuming HuHunan Provincial Center for Disease Control and Prevention, Changsha, 410005, China.
Yafeng XieHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Man XuHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Mingxing LiangHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Wei LiuHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Liangzhuan LiuHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
Yimou WuHunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China; and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China. yimouwu@sina.com.
University of South China · CNHunan Provincial Center for Disease Control and Prevention · CN

Funding

National Natural Science Foundation of China 31270218National Natural Science Foundation of China 31300156
6 · The paper itself

Abstract

Chlamydia psittaci is an obligate intracellular pathogen that can cause zoonosis. Persistent C. psittaci infection can inhibit apoptosis in host cells, thus extending their survival and enabling them to complete their growth cycle. In this study, the antiapoptotic effects of persistent C. psittaci infection, induced by treatment with IFN-γ, were found to be associated with both the death receptor and the mitochondrial pathways of apoptosis. These effects were mediated by Bcl-2 family members, as evidenced by the decreased expression of proapoptotic proteins, such as tBid and Bim. Simultaneously, the antiapoptotic protein Mcl-1 was upregulated by persistent C. psittaci infection. Increased phosphorylation of ERK1/2 was observed; however, the expression of Bad, unlike that of other proapoptotic proteins, did not seem to be involved in this process. In summary, persistent chlamydial infection exerts antiapoptotic effects through both the death receptor and the mitochondrial pathways, in a process that is regulated by the ERK1/2 and apoptotic proteins of the Bcl-2 family.

Indexed as

ApoptosisChlamydophila psittaciApoptosis Regulatory ProteinsBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCell LineHumansInterferon-gammaMAP Kinase Signaling SystemMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2PsittacosisApoptosis Regulatory ProteinsBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinInterferon-gammaMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-bcl-2apoptosisBcl-2 family proteinsChlamydia psittaciIFN-γpersistent infection

Identifiers

PMID29666982
OpenAlexW2800589993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.