Evidence map›Paper›PMID 29666899›Full record

ArticleDiabetologia2018

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes.

Cynthia M F Monaco, Meghan C Hughes, Sofhia V Ramos, Nina E Varah, Christian Lamberz, Fasih A Rahman, Chris McGlory, Mark A Tarnopolsky, Matthew P Krause, Robert Laham and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Pooled it
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  18. iMeta · 2024
    Article
  19. Muscle mitochondrial function is impaired in adults with type 1 diabetes.Journal of diabetes and its complications · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Cynthia M F MonacoDepartment of Pathology and Molecular Medicine, McMaster University, 4N65 Health Sciences Centre, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada.
Meghan C HughesSchool of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, ON, Canada.
Sofhia V RamosSchool of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, ON, Canada.
Nina E VarahDepartment of Pathology and Molecular Medicine, McMaster University, 4N65 Health Sciences Centre, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada.
Christian LamberzGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Fasih A RahmanDepartment of Kinesiology, University of Windsor, Windsor, ON, Canada.
Chris McGloryDepartment of Kinesiology, McMaster University, Hamilton, ON, Canada.
Mark A TarnopolskyDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Matthew P KrauseDepartment of Kinesiology, University of Windsor, Windsor, ON, Canada.
Robert LahamSchool of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, ON, Canada.
Thomas J HawkeDepartment of Pathology and Molecular Medicine, McMaster University, 4N65 Health Sciences Centre, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada. hawke@mcmaster.ca.
Christopher G R PerrySchool of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, ON, Canada.
York University · CAMcMaster University · CAHealth Sciences Centre · CAUniversity of Windsor · CAGerman Center for Neurodegenerative Diseases · DE

Funding

Natural Sciences and Engineering Research Council of Canada 436138-2013
6 · The paper itself

Abstract

aims/hypothesisA comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes.

methodsPhysically active, young adults (men and women) with type 1 diabetes (HbA

resultsMitochondrial oxidative capacity was significantly lower in participants with type 1 diabetes vs the control group, specifically at Complex II of the electron transport chain, without differences in mitochondrial content between groups. Muscles of those with type 1 diabetes also exhibited increased mitochondrial H CONCLUSIONS/

interpretationAlterations in mitochondrial ultrastructure and bioenergetics are evident within the skeletal muscle of active young adults with type 1 diabetes. It is yet to be elucidated whether more rigorous exercise may help to prevent skeletal muscle metabolic deficiencies in both active and inactive individuals with type 1 diabetes.

Indexed as

AdultBody Mass IndexCalciumDiabetes Mellitus, Type 1Energy MetabolismExerciseFemaleHumansHydrogen PeroxideInsulinMaleMicroscopy, Electron, TransmissionMicroscopy, FluorescenceMitochondriaMuscle, SkeletalOxygen ConsumptionCalciumHydrogen PeroxideInsulinCalcium toleranceCapillary densityMitochondriaMyopathyReactive oxygen speciesSkeletal muscleType 1 diabetes

Identifiers

PMID29666899
OpenAlexW2797318793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.