ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2018
SNP-based pool genotyping and haplotype analysis accelerate fine-mapping of the wheat genomic region containing stripe rust resistance gene Yr26.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Genomic analysis of two all-stage stripe rust resistance genes in the Vavilov wheat landrace AGG40807WHEA1.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Development of a KASP marker set for high-throughput genotyping in Japanese barley breeding programs with various end-use purposes.Breeding science · 2025Article
- Genome-wide mapping of quantitative trait loci conferring resistance to stripe rust in spring wheat line PI 660072.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- KASP: a high-throughput genotyping system and its applications in major crop plants for biotic and abiotic stress tolerance.Molecular biology reports · 2024Review
- Fine mapping ofFrontiers in plant science · 2024Article
- Sr65: a widely effective gene for stem rust resistance in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The Detection ofInternational journal of molecular sciences · 2023Article
- Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-aBIOTECH · 2023Review
- Cytological and genetic effects of rye chromosomes 1RS and 3R on the wheat-breeding founder parent Chuanmai 42 from southwestern China.Molecular breeding : new strategies in plant improvement · 2023Article
- Fine Mapping of Stripe-Rust-Resistance GenePlants (Basel, Switzerland) · 2022Article
- A cytosine base editor toolkit with varying activity windows and target scopes for versatile gene manipulation in plants.Nucleic acids research · 2022Article
- Phenotyping and validation of molecular markers associated with rust resistance genes in wheat cultivars in Egypt.Molecular biology reports · 2022Article
- Genetic identification of SNP markers and candidate genes associated with sugarcane smut resistance using BSR-Seq.Frontiers in plant science · 2022Article
- Novel stripe rust all-stage resistance loci identified in a worldwide collection of durum wheat using genome-wide association mapping.The plant genome · 2021Article
- An adult plant stripe rust resistance gene maps on chromosome 7A of Australian wheat cultivar Axe.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genomic Approaches to Identify Molecular Bases of Crop Resistance to Diseases and to Develop Future Breeding Strategies.International journal of molecular sciences · 2021Review
- Predominant wheat-alien chromosome translocations in newly developed wheat of China.Molecular breeding : new strategies in plant improvement · 2021Article
- High-Resolution Mapping of the Novel Early Leaf Senescence GenePlants (Basel, Switzerland) · 2020Article
- Appraisal of wheat genomics for gene discovery and breeding applications: a special emphasis on advances in Asia.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
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Authors and funding
12 authors.
Funding
Abstract
key messageNGS-assisted super pooling emerging as powerful tool to accelerate gene mapping and haplotype association analysis within target region uncovering specific linkage SNPs or alleles for marker-assisted gene pyramiding. Conventional gene mapping methods to identify genes associated with important agronomic traits require significant amounts of financial support and time. Here, a single nucleotide polymorphism (SNP)-based mapping approach, RNA-Seq and SNP array assisted super pooling analysis, was used for rapid mining of a candidate genomic region for stripe rust resistance gene Yr26 that has been widely used in wheat breeding programs in China. Large DNA and RNA super-pools were genotyped by Wheat SNP Array and sequenced by Illumina HiSeq, respectively. Hundreds of thousands of SNPs were identified and then filtered by multiple filtering criteria. Among selected SNPs, over 900 were found within an overlapping interval of less than 30 Mb as the Yr26 candidate genomic region in the centromeric region of chromosome arm 1BL. The 235 chromosome-specific SNPs were converted into KASP assays to validate the Yr26 interval in different genetic populations. Using a high-resolution mapping population (> 30,000 gametes), we confined Yr26 to a 0.003-cM interval. The Yr26 target region was anchored to the common wheat IWGSC RefSeq v1.0 and wild emmer WEWSeq v.1.0 sequences, from which 488 and 454 kb fragments were obtained. Several candidate genes were identified in the target genomic region, but there was no typical resistance gene in either genome region. Haplotype analysis identified specific SNPs linked to Yr26 and developed robust and breeder-friendly KASP markers. This integration strategy can be applied to accelerate generating many markers closely linked to target genes/QTL for a trait of interest in wheat and other polyploid species.
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