Evidence map›Paper›PMID 29666624›Full record

ArticleFrontiers in immunology2018

Recombinant Protein Containing B-Cell Epitopes of Different

Sabrina de Almeida Lima, Clara Guerra-Duarte, Fernanda Costal-Oliveira, Thais Melo Mendes, Luís F M Figueiredo, Daysiane Oliveira, Ricardo A Machado de Avila, Valéria Pereira Ferrer, Dilza Trevisan-Silva, Silvio S Veiga and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sabrina de Almeida LimaDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Clara Guerra-DuarteDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Fernanda Costal-OliveiraDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Thais Melo MendesDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luís F M FigueiredoDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Daysiane OliveiraPrograma de Pós-Graduação em Ciências da Saúde - PPGCS, Universidade do Extremo Sul Catarinense - UNESC, Criciúma, Brazil.
Ricardo A Machado de AvilaPrograma de Pós-Graduação em Ciências da Saúde - PPGCS, Universidade do Extremo Sul Catarinense - UNESC, Criciúma, Brazil.
Valéria Pereira FerrerUniversidade Federal de Paraná, Curitiba, Brazil.
Dilza Trevisan-SilvaUniversidade Federal de Paraná, Curitiba, Brazil.
Silvio S VeigaUniversidade Federal de Paraná, Curitiba, Brazil.
João C MinozzoCentro de Produção e Pesquisa de Imunobiológicos - CPPI, Piraquara, Brazil.
Evanguedes KalapothakisDepartamentos de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Carlos Chávez-OlórteguiDepartamentos de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade do Extremo Sul Catarinense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loxoscelism is the most important form of araneism in South America. The treatment of these accidents uses heterologous antivenoms obtained from immunization of production animals with crude loxoscelic venom. Due to the scarcity of this immunogen, new alternatives for its substitution in antivenom production are of medical interest. In the present work, three linear epitopes for Loxosceles astacin-like protease 1 (LALP-1) (SLGRGCTDFGTILHE, ENNTRTIGPFDYDSIMLYGAY, and KLYKCPPVNPYPGGIRPYVNV) and two for hyaluronidase (LiHYAL) (NGGIPQLGDLKAHLEKSAVDI and ILDKSATGLRIIDWEAWR) from

Indexed as

AnimalsAntibodies, NeutralizingEpitopes, B-LymphocyteFemaleImmunizationMice, Inbred BALB CPhosphoric Diester HydrolasesRabbitsRecombinant ProteinsSpider VenomsAntibodies, NeutralizingEpitopes, B-Lymphocyteloxosceles venomPhosphoric Diester HydrolasesRecombinant ProteinsSpider Venomsastacin-like metalloprotease hyaluronidaseB-cell epitopeLoxosceles spider venommultiepitopic recombinant proteinsphingomyelinase D

Identifiers

PMID29666624
PMCPMC5891610
OpenAlexW2795517288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.