ArticleFrontiers in behavioral neuroscience2018
Psychosocial Stress and Immunity-What Can We Learn From Pig Studies?
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs.PloS one · 2022Pooled it
- Impact of environmental enrichment and allostatic load induced by repeated mixing on the transcriptome of three porcine brain tissues.Molecular brain · 2026Article
- Acute Physiological Response Variability in Lidia Bulls Following Roping Bull Celebrations: Effects of Age, Previous Participation, and Sampling Period.Animals : an open access journal from MDPI · 2026Article
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Insights into pig resilience: the Microbiome-genetic connection.Porcine health management · 2026Review
- Daily feed intake patterns of purebred nucleus boars as genetic indicators for disease resilience of crossbred barrows under a natural polymicrobial disease challenge.Journal of animal science · 2026Article
- Hematological, Enzymatic, and Endocrine Response to Intense Exercise in Lidia Breed Cattle During the Roping Bull Bullfighting Celebration.Animals : an open access journal from MDPI · 2025Article
- Genetic analysis of stress hormone levels in hair of healthy nursery pigs and their relationships with backtest responses.Genetics · 2025Article
- Understanding the Impact of Social Stress on Serum Metabolome and Saliva Biomarkers in Growing-Finishing Pigs.Animals : an open access journal from MDPI · 2025Article
- Classification of resilience to weaning stress using cortisol patterns and associations with growth and behavior in Yorkshire gilts.Journal of animal science · 2025Article
- Manipulating early-life environment and handling alters growth trajectories, immune and stress responses, clinical indicators, and intestinal health in young pigs.Journal of animal science · 2025Article
- A comprehensive analysis of allele-specific expression and transcriptomic profiling in pig limbic and endocrine tissues.Frontiers in molecular neuroscience · 2025Article
- Article
- Stress Biomarkers in Pigs: Current Insights and Clinical Application.Veterinary sciences · 2024Review
- DietaryAnimals : an open access journal from MDPI · 2024Article
- When the neighbors are noisy: effect of social challenge in collateral pens of stressed animals.Frontiers in veterinary science · 2024Article
- Adapted Original Music as an Environmental Enrichment in an Intensive Pig Production System Reduced Aggression in Weaned Pigs during Regrouping.Animals : an open access journal from MDPI · 2023Article
- Road Transport: A Review of Its Effects on the Welfare of Piglets.Animals : an open access journal from MDPI · 2023Review
- Fermented Chinese Herbal Medicine Promoted Growth Performance, Intestinal Health, and Regulated Bacterial Microbiota of Weaned Piglets.Animals : an open access journal from MDPI · 2023Article
- Hierarchy Establishment in Growing Finishing Pigs: Impacts on Behavior, Growth Performance, and Physiological Parameters.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychosocial stress may impair immune functions and provoke the development of pathologies. The underlying communication between the brain and the immune system is being studied predominantly in rodents. However, pigs offer several advantages as preclinical models for humans because pigs are more similar to humans than rodents in many anatomical and physiological characteristics. Unlike in rodents, the main stress-induced glucocorticoid in humans and pigs is cortisol with a similar circadian rhythm. In this study, we summarize data on short-term and long-term effects of social stress in pigs for their immunity and neuroendocrine regulation with consequences for their health and well-being. As typical social stressors, regrouping, crowding, social isolation, and maternal deprivation have been studied. Psychosocial stress in pigs may affect various reactions of innate and adaptive immunity, such as leukocyte distribution, cytokine secretion, lymphocyte proliferation, and antibody production as well as immune responses to viral infection or vaccination. Furthermore, social stress may induce or promote gastrointestinal diseases through dysregulation of inflammatory processes. In piglets, psychosocial stress may also result in glucocorticoid resistance of lymphocytes, which has been discussed as a cause of allergic asthma in humans. Stress-related neuroendocrine alterations in the cortico-limbic structures, such as the prefrontal cortex, amygdala, hippocampus and hypothalamus, have been demonstrated in pigs at different ages. Based on these data, we propose using pigs as models for psychosocial stress in humans to study the mechanisms of brain-to-immune and immune-to-brain communication from the systemic level down to the cellular and subcellular levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.