Evidence map›Paper›PMID 29666564›Full record

ArticleContrast media & molecular imaging2018

Neural Induction Potential and MRI of ADSCs Labeled Cationic Superparamagnetic Iron Oxide Nanoparticle In Vitro.

Weiqiong Ma, Qi Xie, Baolin Zhang, Huixian Chen, Jianyi Tang, Zhengxian Lei, Minyi Wu, Dingxuan Zhang, Jiani Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Weiqiong MaMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Qi XieMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.ORCID 0000-0003-1562-1929
Baolin ZhangSchool of Materials Science and Engineering, Guilin University of Technology, Guilin, Guangxi 541004, China.ORCID 0000-0002-2238-3351
Huixian ChenMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Jianyi TangMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Zhengxian LeiMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Minyi WuMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Dingxuan ZhangMedical Imaging Department, Nan Sha Center Hospital, Guangzhou Municipal First People's Hospital, Guangzhou Medical University, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 511457, China.
Jiani HuKarmanos Cancer Institute, Wayne State University, 3990 John R. Street, Detroit, MI 48201, USA.
Guangzhou First People's Hospital · CNGuilin University of Technology · CNWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES). After neural induction, nestin and NSE (neural markers) were obviously expressed. In vitro MRI showed that the cationic PEG/PEI-modified SPIO nanoparticles could achieve great relaxation performance and favourable longevity. And the ICP-AES quantified the lowest iron content that could be detected by MRI as 1.56~1.8 pg/cell. This study showed that the cationic SPIO could be directly used to label ADSCs, which could then inductively differentiate into nerve and be imaged by in vitro MRI, which would exhibit important guiding significance for the further in vivo MRI towards animal models with neurodegenerative disorders.

Indexed as

Magnetite NanoparticlesAdipose TissueAnimalsCationsCells, CulturedCell TrackingMagnetic Resonance ImagingNeurodegenerative DiseasesNeuronsRatsStaining and LabelingStem CellsCationsMagnetite Nanoparticles

Identifiers

PMID29666564
PMCPMC5832102
OpenAlexW2789449907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.