ReviewNature reviews. Molecular cell biology2018
Single-cell transcriptional profiling: a window into embryonic cell-type specification.
Review in Nature reviews. Molecular cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Dissecting the expression pattern during embryonic development and unveiling sustained ZGA genes with oncogenic relevance.BMC genomics · 2026Article
- Single-cell mitochondrial lineage tracing: Opportunities and challenges.Quantitative biology (Beijing, China) · 2026Review
- E-cadherin negatively regulates hESCs endodermal differentiation under varied substrate stiffnesses.Cellular and molecular life sciences : CMLS · 2025Article
- BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells.Frontiers in bioengineering and biotechnology · 2025Article
- Integrated analysis of single-cell and bulk RNA-seq reveals MAGEA3/6-associated immune subtypes and key immune genes in gastric cancer.PloS one · 2025Article
- Beaconet: A Reference-Free Method for Integrating Multiple Batches of Single-Cell Transcriptomic Data in Original Molecular Space.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside.Basic research in cardiology · 2023Review
- HUSCH: an integrated single-cell transcriptome atlas for human tissue gene expression visualization and analyses.Nucleic acids research · 2023Article
- ResPAN: a powerful batch correction model for scRNA-seq data through residual adversarial networks.Bioinformatics (Oxford, England) · 2022Article
- Cell Trafficking at the Intersection of the Tumor-Immune Compartments.Annual review of biomedical engineering · 2022Review
- The Promise of Single-cell Technology in Providing New Insights Into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia.HemaSphere · 2022Review
- Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.Nature communications · 2022Article
- Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation.PLoS genetics · 2022Article
- Single-cell mapping of DNA G-quadruplex structures in human cancer cells.Scientific reports · 2021Article
- Transposable elements shape the evolution of mammalian development.Nature reviews. Genetics · 2021Review
- iMAP: integration of multiple single-cell datasets by adversarial paired transfer networks.Genome biology · 2021Article
- In vivo and ex vivo haematopoietic stem cell expansion.Current opinion in hematology · 2020Review
- Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.Nature cell biology · 2020Article
- Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.Nature medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
During mammalian embryonic development, a single fertilized egg cell will proliferate and differentiate into all the cell lineages and cell types that eventually form the adult organism. Cell lineage diversification involves repeated cell fate choices that ultimately occur at the level of the individual cell rather than at the cell-population level. Improvements in single-cell technologies are transforming our understanding of mammalian development, not only by overcoming the limitations presented by the extremely low cell numbers of early embryos but also by enabling the study of cell fate specification in greater detail. In this Review, we first discuss recent advances in single-cell transcriptomics and imaging and provide a brief outline of current bioinformatics methods available to analyse the resulting data. We then discuss how these techniques have contributed to our understanding of pre-implantation and early post-implantation development and of in vitro pluripotency. Finally, we overview the current challenges facing single-cell research and highlight the latest advances and potential future avenues.
Indexed as
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29666443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.