ArticleScientific reports2018
Psoriasis patients demonstrate HLA-Cw*06:02 allele dosage-dependent T cell proliferation when treated with hair follicle-derived keratin 17 protein.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel Therapies.International journal of molecular sciences · 2025Review
- Gender differences in the association between adverse childhood experiences and early onset psoriasis.Scientific reports · 2025Article
- Triggers for the onset and recurrence of psoriasis: a review and update.Cell communication and signaling : CCS · 2024Review
- KRT17 from skin cells with high glucose stimulation promotes keratinocytes proliferation and migration.Frontiers in endocrinology · 2023Article
- Antigen-Presenting Cells in Psoriasis.Life (Basel, Switzerland) · 2022Article
- New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.The Journal of investigative dermatology · 2021Review
- HLA-Cw1 and Psoriasis.American journal of clinical dermatology · 2021Review
- Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese.BioMed research international · 2021Article
- The Role of Helper T Cells in Psoriasis.Frontiers in immunology · 2021Review
- Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections.Vaccines · 2020Review
- Interleukin-17A and Keratinocytes in Psoriasis.International journal of molecular sciences · 2020Review
- The contribution of IL-17 to the development of autoimmunity in psoriasis.Innate immunity · 2019Review
- Psoriasis Pathogenesis and Treatment.International journal of molecular sciences · 2019Review
- Defining Early Life Stress as a Precursor for Autoimmune Disease.Critical reviews in immunology · 2019Review
- Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.Frontiers in immunology · 2018Review
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is broadly accepted that psoriasis is an immune-mediated disease with a heritable component, but it is not clear what causes inflammation in the skin. Previous research suggests that fragments of the keratin 17 (K17) protein, which are constitutively expressed in hair follicles, could act as autoantigens. In this study, we synthesized the K17 protein from mRNA derived from hair follicles and tested whether it elicited T cell responses depending on the patient genotype at the major susceptibility locus HLA-Cw*06:02. We treated peripheral blood-derived cells with the K17 protein and its short fragments to assess the T cell proliferation response using flow cytometry. Our analyses show a significantly stronger increase in cell proliferation among patients but not in healthy controls. We then examined whether the variation in T cell proliferation correlated with the patient HLA-Cw*06:02 risk genotype. Considering the affected status and patient genotype as two independent predictors, we fitted a linear model and showed that the HLA-Cw*06:02 allele dosage strongly predicted the T cell response. Our study findings suggest that the K17 protein likely acts as an autoantigen in psoriasis and that patients' risk genotype is strongly correlated with the magnitude of the response to this putative autoantigen.
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