ArticleScientific reports2018
Effect of antibiotic use for acute bronchiolitis on new-onset asthma in children.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Recurrent wheezing as a mediator between early-life exposures and childhood asthma: a mediation analysis in an Italian primary care paediatric cohort.BMJ public health · 2026Article
- Predictors of recurrent wheezing in late preterm infants.Pediatric pulmonology · 2024Article
- Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis.NEJM evidence · 2022Article
- Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.The World Allergy Organization journal · 2021Article
- Early Life Factors Associated with Preschool Wheezing in Preterm Infants.Children (Basel, Switzerland) · 2021Article
- The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population.Contemporary clinical trials communications · 2021Article
- The effects of antibiotic exposure on asthma in children with atopic dermatitis.Scientific reports · 2021Article
- Costs of Respiratory Syncytial Virus Hospitalizations in Colombia.PharmacoEconomics - open · 2021Article
- Association between air pollutants and outpatient and emergency hospital visits for childhood asthma in Shenyang city of China.International journal of biometeorology · 2020Article
- First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses.International journal of environmental research and public health · 2020Article
- The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma.Respiratory research · 2020Review
- Azithromycin in acute bronchiolitis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year. We identified age at asthma onset, sex, residential area, history of atopy and NSAID use, age at first use of antibiotics, and the specific antibiotic, and adjusted for these factors using conditional logistic regression analysis. Among all individuals, there was a relationship between risk of new-onset asthma with use of a high dose of an antibiotic (adjusted odds ratio [aOR] = 3.33, 95% confidence interval [CI] = 2.67-4.15). Among the different antibiotics, macrolides (aOR = 2.87, 95% CI = 1.99-4.16), and azithromycin specifically (aOR = 3.45, 95% CI = 1.62-7.36), had the greatest effect of development of asthma.
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