Evidence map›Paper›PMID 29666364›Full record

ArticleNature communications2018

Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP.

Yaxiong Yang, Nan Liu, Yuanyuan He, Yuxia Liu, Lin Ge, Linzhi Zou, Sen Song, Wei Xiong, Xiaodong Liu

Open access · goldAbstract readValidation Study
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.

  1. Pooled it
  2. Host-derived stimuli alter intracellular calcium levels inApplied and environmental microbiology · 2026
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  13. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.Proceedings of the National Academy of Sciences of the United States of America · 2025
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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yaxiong YangDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.ORCID http://orcid.org/0000-0002-3313-6049
Nan LiuDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.
Yuanyuan HeDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.
Yuxia LiuDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.
Lin GeDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.
Linzhi ZouSchool of Life Sciences, Tsinghua University, Beijing, 100084, China.
Sen SongDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China.
Wei XiongIDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, 100084, China.
Xiaodong LiuDepartment of Biomedical Engineering, School of Medicine, X-Lab for Transmembrane Signaling Research, Tsinghua University, Beijing, 100084, China. liu-lab@vip.163.com.ORCID http://orcid.org/0000-0002-3171-9611
Tsinghua University · CNChinese Institute for Brain Research · CNKunming University · CNMcGovern Institute for Brain Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GCaMP, one popular type of genetically-encoded Ca

Indexed as

Calcium SignalingAnimalsBiosensing TechniquesCalciumCalcium Channels, L-TypeCalmodulinFluorescent DyesGenetic EngineeringGreen Fluorescent ProteinsHEK293 CellsHumansIntravital MicroscopyIon Channel GatingMiceMice, Inbred ICRMolecular ImagingCalciumCalcium Channels, L-TypeCalmodulinFluorescent DyesGreen Fluorescent Proteins

Identifiers

PMID29666364
PMCPMC5904127
OpenAlexW2802576439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.