Trial reportProceedings of the National Academy of Sciences of the United States of America2018
Spatial and temporal heterogeneity of neural responses in human posteromedial cortex.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Neural Electrical Correlates of Subjective Happiness.Human brain mapping · 2025Article
- Article
- Article
- Default mode network electrophysiological dynamics and causal role in creative thinking.Brain : a journal of neurology · 2024Article
- Electrophysiological dynamics of salience, default mode, and frontoparietal networks during episodic memory formation and recall: A multi-experiment iEEG replication.bioRxiv : the preprint server for biology · 2024Article
- Cross-regional coordination of activity in the human brain during autobiographical self-referential processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Frequency-specific directed connectivity between the hippocampus and parietal cortex during verbal and spatial episodic memory: an intracranial EEG replication.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Hippocampal-parietal cortex causal directed connectivity during human episodic memory formation: Replication across three experiments.bioRxiv : the preprint server for biology · 2024Article
- Analyzing top-down visual attention in the context of gamma oscillations: a layer- dependent network-of- networks approach.Frontiers in computational neuroscience · 2024Article
- A tripartite view of the posterior cingulate cortex.Nature reviews. Neuroscience · 2023Review
- Central precuneus lesions are associated with impaired executive function.Brain structure & function · 2022Article
- Review
- Article
- Electrophysiological foundations of the human default-mode network revealed by intracranial-EEG recordings during resting-state and cognition.NeuroImage · 2022Article
- Electrocorticographic evidence of a common neurocognitive sequence for mentalizing about the self and others.Nature communications · 2022Article
- Mind-wandering: mechanistic insights from lesion, tDCS, and iEEG.Trends in cognitive sciences · 2022Review
- Functional network antagonism and consciousness.Network neuroscience (Cambridge, Mass.) · 2022Article
- Article
- Altered sense of self during seizures in the posteromedial cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Top-Down Attentional Modulation in Human Frontal Cortex: Differential Engagement during External and Internal Attention.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Neuroimaging evidence supports a role of the default mode network (DMN) in spontaneous thought and goal-driven internally oriented processes, such as recalling an autobiographical event, and has demonstrated its deactivation during focused, externally oriented attention. Recent work suggests that the DMN is not a homogeneous network but rather is composed of at least several subnetworks, which are engaged in distinct functions; however, it is still unclear if these different functions rely on the same neuronal populations. In this study, we used intracranial EEG to record from the posteromedial cortex (PMC), a core hub of the DMN, in 13 human subjects, during autobiographical memory retrieval (internally oriented), arithmetic processing (externally oriented), and cued rest (spontaneous thought), allowing us to measure activity from anatomically precise PMC sites with high temporal resolution. We observed a heterogeneous, yet spatially organized, pattern of activity across tasks. Many sites, primarily in the more ventral portion of PMC, were engaged during autobiographical recall and suppressed during arithmetic processing. Other more dorsal PMC sites were engaged during the cued-rest condition. Of these rest-active sites, some exhibited variable temporal dynamics across trials, possibly reflecting various forms of spontaneous thought, while others showed only transient activity at the beginning of cued-rest trials (i.e., after a switch from a task to cued rest), possibly involved in shifting the brain from a more focused to a more exploratory attentional state. These results suggest heterogeneity of function even within an individual node of the DMN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.