ArticleProceedings of the National Academy of Sciences of the United States of America2018
Shared epitope-aryl hydrocarbon receptor crosstalk underlies the mechanism of gene-environment interaction in autoimmune arthritis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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47 citing papers in PubMed, 77 citations in OpenAlex.
- Engineered probiotic-derived indole-3-propionic acid inhibits ubiquitination via AHR signaling to treat postmenopausal osteoporosis.Gut microbes · 2026Article
- Particulate Matter-Induced Skin Injury: A Dual-Pathway AhR-Nrf2 Framework for Epidermal Homeostasis and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential.Pharmacological reviews · 2026Review
- Shared Epitope-PositiveNeurology(R) neuroimmunology & neuroinflammation · 2026Article
- The Linkage Between Ecotoxins Within Maximum Permissible Concentrations, Oxidative Stress and Antibodies Against Cyclic Citrullinated Peptides in Patients and Persons at Preclinic Stages of Rheumatoid Arthritis.International journal of molecular sciences · 2026Article
- Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.International journal of biological sciences · 2026Review
- Human intestinal fungus Clavispora lusitaniae attenuates colitis through Pyruvate decarboxylase-derived Indole-3-ethanol.Nature communications · 2025Article
- In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways.Current pharmaceutical biotechnology · 2025Review
- Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis.Research (Washington, D.C.) · 2025Review
- Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study.Scientific reports · 2024Article
- A hierarchical cluster analysis for clinical profiling of tofacitinib treatment response in patients with rheumatoid arthritis.Clinical rheumatology · 2024Article
- Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis.Journal of orthopaedic translation · 2024Review
- Single-cell RNA sequencing in juvenile idiopathic arthritis.Genes & diseases · 2024Review
- Aryl hydrocarbon receptor gene expression in ankylosing spondylitis and its correlation with interleukin-17, RAR-related orphan receptor gamma t expression, and disease activity indices.Archives of rheumatology · 2024Article
- The Role of the Aryl Hydrocarbon Receptor in Vascular Factors Related to Preeclampsia in a Smoking Mouse Model.Current issues in molecular biology · 2024Article
- Noncoding RNAs in rheumatoid arthritis: modulators of the NF-κB signaling pathway and therapeutic implications.Frontiers in immunology · 2024Review
- The role of aryl hydrocarbon receptor in the occurrence and development of periodontitis.Frontiers in immunology · 2024Review
- The Role of Aryl Hydrocarbon Receptor in Bone Biology.International journal of tryptophan research : IJTR · 2024Review
- Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination.Journal of neuroinflammation · 2023Article
- Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway.Biochemical pharmacology · 2023Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Jiaqi FuDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Sarah V NogueiraDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Vincent van DrongelenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Patrick CoitDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Song LingDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Edward F RosloniecVeterans Affairs Medical Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163.
Amr H SawalhaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Joseph HoloshitzDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; jholo@umich.edu.
University of Michigan–Ann Arbor · USUniversity of Tennessee Health Science Center · US
Funding
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MTRAINING OF ARTHRITIS RESEARCH SCIENTISTST32AR007080 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 1986 to 2026
$6.3MImmune Modulating HLA-Coded Ligands in Rheumatoid ArthritisR01AR059085 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2011 to 2020
$3.8MGene-environment interaction pathways in rheumatoid arthritisR01AR074930 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2019 to 2023
$2.6MClass II MHC Allele-Specific Signaling: A New Paradigm in Disease PathogenesisR01GM088560 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2009 to 2012
$1.2MEmpirical validation of a novel HLA-disease association theory in skin and rheumatic diseasesR61AR073014 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2017 to 2018
$770kA novel mechanism of gene-environment interaction in autoimmune arthritisR21ES024428 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2014 to 2015
$427kEmpirical validation of a novel HLA-disease association theory in skin and rheumatic diseasesR33AR073014 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLOSHITZ, JOSEPH · 2019 to 2019
$390kNIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR059085NIAMS NIH HHS R01 AR074930NIAMS NIH HHS R33 AR073014NIAMS NIH HHS R61 AR073014NIAMS NIH HHS T32 AR007080NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R21 ES024428NIGMS NIH HHS R01 GM088560
Abstract
The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated
Indexed as
Arthritis, ExperimentalGene-Environment InteractionReceptors, Aryl HydrocarbonSignal TransductionTh17 CellsAllelesAnimalsEnvironmental PollutantsEpitopesHumansMiceMice, TransgenicEnvironmental PollutantsEpitopesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorgene–environment interactionnuclear factor kappa Bshared epitopesignaling
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.