Evidence map›Paper›PMID 29666244›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Spatial determinants of quorum signaling in a

Sophie E Darch, Olja Simoska, Mignon Fitzpatrick, Juan P Barraza, Keith J Stevenson, Roger T Bonnecaze, Jason B Shear, Marvin Whiteley

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 151 citations in OpenAlex.

  1. Review
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  11. Exploring aggregation genes in aJournal of bacteriology · 2025
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  19. Co-occurring microflora and mucin driveISME communications · 2024
    Article
  20. ReducingAnalytical chemistry · 2023
    Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sophie E DarchSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Olja SimoskaDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Mignon FitzpatrickDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Juan P BarrazaSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Keith J StevensonCenter for Electrochemical Energy Storage, Skolkovo Institute of Science and Technology, 143026 Moscow, Russia.
Roger T BonnecazeDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712.
Jason B ShearDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712; jshear@cm.utexas.edu marvin.whiteley@biosci.gatech.edu.
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332; jshear@cm.utexas.edu marvin.whiteley@biosci.gatech.edu.
The University of Texas at Austin · USGeorgia Institute of Technology · USSkolkovo Institute of Science and Technology · RU

Funding

Mechanisms of Pseudomonas aeruginosa virulence in polymicrobial wound infectionsR01GM116547 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM116547
6 · The paper itself

Abstract

Quorum sensing (QS) is a bacterial communication system that involves production and sensing of extracellular signals. In laboratory models, QS allows bacteria to monitor and respond to their own cell density and is critical for fitness. However, how QS proceeds in natural, spatially structured bacterial communities is not well understood, which significantly hampers our understanding of the emergent properties of natural communities. To address this gap, we assessed QS signaling in the opportunistic pathogen

Indexed as

Models, BiologicalCystic FibrosisHumansPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingSignal Transductionaggregatecystic fibrosisPseudomonas aeruginosaquorum sensingspatial distribution

Identifiers

PMID29666244
PMCPMC5939081
OpenAlexW2801535289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.