Evidence map›Paper›PMID 29666187›Full record

ArticleThe Journal of biological chemistry2018

A putative G-quadruplex structure in the proximal promoter of

Yaping Liu, Wenxian Lan, Chunxi Wang, Chunyang Cao

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Review
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  9. Article
  10. Sugar Puckering Drives G-Quadruplex Refolding: Implications for V-Shaped Loops.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  11. Article
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  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yaping LiuFrom the State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry and.
Wenxian LanFrom the State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry and.
Chunxi WangFrom the State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry and.
Chunyang CaoFrom the State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry and ccao@mail.sioc.ac.cn.
University of Chinese Academy of Sciences · CNChinese Academy of Sciences · CNShanghai Institute of Organic Chemistry · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor angiogenesis is mainly regulated by vascular endothelial growth factor (VEGF) produced by cancer cells. It is active on the endothelium via VEGF receptor 2 (VEGFR-2). G-quadruplexes are DNA secondary structures formed by guanine-rich sequences, for example, within gene promoters where they may contribute to transcriptional activity. The proximal promoter of

Indexed as

Drug DesignG-QuadruplexesAngiogenesis InhibitorsBase SequenceHumansModels, MolecularNeoplasmsNeovascularization, PathologicPromoter Regions, GeneticSmall Molecule LibrariesVascular Endothelial Growth Factor Receptor-2Angiogenesis InhibitorsSmall Molecule LibrariesVascular Endothelial Growth Factor Receptor-2angiogenesisDNA structureG-quadruplexnuclear magnetic resonance (NMR)vascular endothelial growth factor (VEGF)VEGFR-2

Identifiers

PMID29666187
PMCPMC5995518
OpenAlexW2801640971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.