Evidence map›Paper›PMID 29666182›Full record

ArticleThe Journal of biological chemistry2018

A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the

Tianji Ma, Baiying Li, Ryan Wang, Pik Ki Lau, Yan Huang, Liwen Jiang, Randy Schekman, Yusong Guo

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Uncovering cargo clients and accessory factors of AP-1 and AP-4 through vesicle proteomics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Conventional and Unconventional Protein Secretion in Yeast and Animal Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  8. Review
  9. Review
  10. An in vitro vesicle formation assay reveals cargo clients and factors that mediate vesicular trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Visualization of Protein Sorting at theFrontiers in cell and developmental biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tianji MaFrom the Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Baiying Lithe Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Ryan Wangthe Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, and.ORCID 0000-0002-0635-0365
Pik Ki LauFrom the Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Yan HuangFrom the Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Liwen Jiangthe Centre for Cell and Developmental Biology, State Key Laboratory of Agrobiotechnology, School of Life Sciences, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Randy Schekmanthe Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, and.
Yusong GuoFrom the Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China, guoyusong@ust.hk.ORCID 0000-0002-5539-599X
Hong Kong University of Science and Technology · HKChinese University of Hong Kong · HKUniversity of California, Berkeley · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

In planar cell polarity (PCP), the epithelial cells are polarized along the plane of the cell surface perpendicular to the classical apical-basal axis, a process mediated by several conserved signaling receptors. Two PCP-signaling proteins, VANGL planar cell polarity protein 2 (Vangl2) and Frizzled6 (Fzd6), are located asymmetrically on opposite boundaries of the cell. Examining sorting of these two proteins at the

Indexed as

Cell PolarityAmino Acid SequenceCell MembraneFrizzled ReceptorsHEK293 CellsHeLa CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsProtein BindingProtein TransportSequence Homologytrans-Golgi NetworkFrizzled ReceptorsIntracellular Signaling Peptides and ProteinsMembrane ProteinsVANGL2 protein, humanadaptor proteinprotein secretionprotein sortingprotein trafficking (Golgi)vesicles

Identifiers

PMID29666182
PMCPMC5986227
OpenAlexW2800494880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.