Evidence map›Paper›PMID 29666070›Full record

ArticleCirculation2018

Gata4-Dependent Differentiation of c-Kit

Bryan D Maliken, Onur Kanisicak, Jason Karch, Hadi Khalil, Xing Fu, Justin G Boyer, Vikram Prasad, Yi Zheng, Jeffery D Molkentin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bryan D MalikenCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Onur KanisicakCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Jason KarchCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Hadi KhalilCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Xing Fu
Justin G BoyerCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Vikram PrasadCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Yi ZhengCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Jeffery D MolkentinCincinnati Children's Hospital Medical Center, University of Cincinnati, OH (B.D.M., O.K., J.K., H.K., X.F., J.G.B., V.P., Y.Z., J.D.M.).
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Molecular Pathways Controlling Cardiac Gene ExpressionR37HL060562 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MOLKENTIN, JEFFERY D · 2008 to 2017
$3.8M
Paracrine hypothesis underlying cardiac stem cell therapyR01HL132391 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R, MOLKENTIN, JEFFERY D · 2016 to 2019
$3.1M
Cardiovascular Impact of Gata4 Loss in the c-Kit LineageF30HL137239 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MALIKEN, BRYAN D · 2017 to 2019
$131k
NHLBI NIH HHS F30 HL137239NHLBI NIH HHS R01 HL132391NHLBI NIH HHS R37 HL060562NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

backgroundAlthough c-Kit

methodsKit allele-dependent lineage tracing and fusion analysis were performed in mice following simultaneous Gata4 and Gata6 cell type-specific deletion to examine rates of putative de novo cardiomyocyte formation from c-Kit

resultsDeletion of Gata4 in Kit lineage-derived endothelial cells or in total endothelial cells using the Tie2

conclusionsPast identification of presumed de novo cardiomyocyte formation in the heart from c-Kit

Indexed as

Cell LineageCell ProliferationNeovascularization, PhysiologicRegenerationAnimalsBone Marrow TransplantationCell FusionCells, CulturedCell TrackingEndothelial CellsFemaleGATA4 Transcription FactorGATA6 Transcription FactorLeukocytesMaleMice, Inbred C57BLGata4 protein, mouseGATA4 Transcription FactorGata6 protein, mouseGATA6 Transcription FactorProto-Oncogene Proteins c-kitangiogenesismice, transgenicmyocardial infarctionmyocytes, cardiacregeneration

Identifiers

PMID29666070
PMCPMC6125755
OpenAlexW2799903110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.