Evidence map›Paper›PMID 29665854›Full record

ArticleTrials2018

A community-based physical activity intervention to prevent mobility-related disability for retired older people (REtirement in ACTion (REACT)): study protocol for a randomised controlled trial.

Afroditi Stathi, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Antonieta Medina-Lara, Colin Green, James Bilzon, Selena Gray, Heidi Johansen-Berg and 10 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Afroditi StathiSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. A.Stathi@bham.ac.uk.ORCID http://orcid.org/0000-0003-2162-777X
Janet WithallDepartment for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Colin J GreavesUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
Janice L ThompsonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Gordon TaylorDepartment for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Antonieta Medina-LaraUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
Colin GreenUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
James BilzonDepartment for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Selena GrayFaculty of Health and Applied Sciences (HAS), University of the West of England (UWE Bristol), Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK.
Heidi Johansen-BergWellcome Centre for Integrative Neuroimaging, FMRIB, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Claire E SextonWellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Max J WesternDepartment for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Jolanthe L de KoningDepartment for Health, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Jessica C BollenUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
Sarah J MoorlockSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Naiara DemnitzWellcome Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Poppy SeagerWellcome Centre for Integrative Neuroimaging, FMRIB, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Jack M GuralnikDepartment of Epidemiology and Public Health, University of Maryland, School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201-1559, USA.
W Jack RejeskiDepartment of Health and Exercise Science, Wake Forest University, Worrell Professional Center 2164B, PO Box 7868, Winston-Salem, NC, 27109, USA.
Ken R FoxCentre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, BS8 1TZ, UK.

Funding

Department of Health 13/164/51Department of Health PHR/13/164/51Medical Research Council MR/P021220/1Wellcome Trust
6 · The paper itself

Abstract

backgroundThe REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/

designA sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention. The REACT study incorporates comprehensive process and economic evaluation and a nested sub-study which will test the hypothesis that the REACT intervention will slow the rate of brain atrophy and of decline in cognitive function assessed using magnetic resonance imaging (MRI). Outcome data will be collected at baseline, 6, 12 and 24 months for the main study, with MRI sub-study data collected at baseline, 6 and 12 months. The primary outcome analysis (SPPB score at 24 months) will be undertaken blinded to group allocation. Primary comparative analyses will be on an intention-to-treat (ITT) basis with due emphasis placed on confidence intervals. DISCUSSION: REACT represents the first large-scale, pragmatic, community-based trial in the UK to target the non-disabled but high-risk segment of the older population with an intervention to reduce mobility-related disability. A programme that can successfully engage this population in sufficient activity to improve strength, aerobic capacity, coordination and balance would have a major impact on sustaining health and independence. REACT is also the first study of its kind to conduct a full economic and comprehensive process evaluation alongside the RCT. If effective and cost-effective, the REACT intervention has strong potential to be implemented widely in the UK and elsewhere.

trial registrationISRCTN, ID: ISRCTN45627165 . Retrospectively registered on 13 June 2016. Trial sponsor: University of Bath. Protocol Version 1.5.

Indexed as

Community Health ServicesExerciseHealth Services for the AgedMobility LimitationRetirementSedentary BehaviorActivities of Daily LivingAgedAge FactorsCost-Benefit AnalysisDisability EvaluationEnglandFemaleGeriatric AssessmentHealth Care CostsHealth PromotionDisability preventionFrailtyMobility disabilityOlder adultsPhysical activityPhysical functionRandomised control trial

Identifiers

PMID29665854
PMCPMC5905123

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.