ArticleBreast cancer research : BCR2018
Common genetic variation and novel loci associated with volumetric mammographic density.
Article in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Interactions between genetic and epidemiological factors influencing mammographic density.American journal of epidemiology · 2026Article
- Genome-wide association study of Asian women identifies putative mammographic density-associated loci.Breast cancer research : BCR · 2025Article
- Incorporating Continuous Mammographic Density Into the BOADICEA Breast Cancer Risk Prediction Model.JCO precision oncology · 2025Article
- Inhibin subunit beta B (INHBB): an emerging role in tumor progression.Journal of physiology and biochemistry · 2024Review
- Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Nature communications · 2024Article
- The mediating role of mammographic density in the protective effect of early-life adiposity on breast cancer risk: a multivariable Mendelian randomization study.medRxiv : the preprint server for health sciences · 2023Article
- Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia.Breast cancer research and treatment · 2023Article
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- Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci.Breast cancer research : BCR · 2022Article
- Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.Communications biology · 2022Article
- Mammographic features are associated with cardiometabolic disease risk and mortality.European heart journal · 2021Article
- Heritability of mammographic breast density.Quantitative imaging in medicine and surgery · 2020Article
- Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.Nature communications · 2020Article
- The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study.Acta radiologica (Stockholm, Sweden : 1987) · 2020Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundMammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained.
methodsWe conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations with volumetric MD phenotypes (percent dense volume, absolute dense volume, and absolute nondense volume) were estimated using linear regression adjusting for age, body mass index, menopausal status, and six principal components. We also estimated the proportion of MD variance explained by additive contributions from single-nucleotide polymorphisms (SNP-based heritability [h
resultsIn total, three novel MD loci were identified (at P < 5 × 10
conclusionsThese findings provide new insights into the genetic basis of MD and biological mechanisms linking MD to breast cancer risk. Apart from identifying three novel loci, we demonstrate that at least 25% of the MD variance is explained by common genetic variation with h
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