Evidence map›Paper›PMID 29665793›Full record

ArticleBMC nephrology2018

Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations.

Cyril Cyrus, Samir Al-Mueilo, Chittibabu Vatte, Shahanas Chathoth, Yun R Li, Hatem Qutub, Rudaynah Al Ali, Fahad Al-Muhanna, Matthew B Lanktree, Khaled Riyad Alkharsah and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
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  4. Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Cyril CyrusInstitute for Research and Medical Consultation, Imam Abdulrahman bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia. ccyrus@iau.edu.sa.ORCID 0000-0001-7333-6486
Samir Al-MueiloKing Fahd Hospital of the University, Imam Abdulrahman bin Faisal University , Alkhobar, Saudi Arabia.
Chittibabu VatteInstitute for Research and Medical Consultation, Imam Abdulrahman bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Shahanas ChathothInstitute for Research and Medical Consultation, Imam Abdulrahman bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Yun R LiPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hatem QutubKing Fahd Hospital of the University, Imam Abdulrahman bin Faisal University , Alkhobar, Saudi Arabia.
Rudaynah Al AliKing Fahd Hospital of the University, Imam Abdulrahman bin Faisal University , Alkhobar, Saudi Arabia.
Fahad Al-MuhannaKing Fahd Hospital of the University, Imam Abdulrahman bin Faisal University , Alkhobar, Saudi Arabia.
Matthew B LanktreeNephrology Division, Department of Medicine, McMaster University, Hamilton, ON, L8N 4A6, Canada.
Khaled Riyad AlkharsahInstitute for Research and Medical Consultation, Imam Abdulrahman bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Abdullah Al-RubaishKing Fahd Hospital of the University, Imam Abdulrahman bin Faisal University , Alkhobar, Saudi Arabia.
Brian Kim-MozeleskiPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brendan KeatingPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amein Al AliInstitute for Research and Medical Consultation, Imam Abdulrahman bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
King Fahd Hospital of the University · SAImam Abdulrahman Bin Faisal University · SAUniversity of Pennsylvania · USKing Faisal University · SAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were selected to evaluate their association and prevalence in a Saudi Arabian patient cohort with chronic kidney disease (CKD).

methodsEight genetic variants in four genes (SHROOM3, MYH9, SLC7A9, and CST3) were genotyped in 160 CKD patients and 189 ethnicity-matched healthy controls. Genetic variants were tested for association with the development of CKD (eGFR < 60 ml/min/1.73m

resultsAll eight variants were present in Saudi populations with minor allele frequency ranging from 16 to 46%. The risk variant in all four genes demonstrated the same direction of effect as observed in European populations. One variant, rs4821480, in MYH9 was significantly associated with increased risk of development of CKD (OR = 1.69, 95% CI 1.22-2.36, P = 0.002), but the additional variants were not statistically significant given our modest sample size.

conclusionsCKD risk variants identified in European populations are present in Saudis. We did not find evidence to suggest heterogeneity of effect size compared to previously published estimates in European populations. Multivariable logistic regression analysis showed a statistically significant improvement in predicting the CKD using models with either FGF23 and vitamin D or FGF23, vitamin D level, and MYH9 genotypes (AUC = 0.93, 95% CI 0.90-0.95, P <  0.0001).

Indexed as

Polymorphism, Single NucleotideAdultAgedAllelesAmino Acid Transport Systems, BasicCase-Control StudiesCholecalciferolCystatin CFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsGenotypeGlomerular Filtration RateHumansMaleMicrofilament ProteinsAmino Acid Transport Systems, BasicCholecalciferolCST3 protein, humanCystatin CFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsMicrofilament ProteinsMolecular Motor ProteinsMYH9 protein, humanMyosin Heavy ChainsSHROOM3 protein, humanSLC7A9 protein, humanChronic kidney diseaseCST3Genetic biomarkersMYH9SHROOM3SLC7A9SNP

Identifiers

PMID29665793
PMCPMC5905143
OpenAlexW2801932994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.