ArticleBMC neurology2018
Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report.
Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Fahr's disease presenting with ischemic stroke in young adult: a case report of rare disease with unique presentation.Annals of medicine and surgery (2012) · 2025Article
- Multi territory ischemic stroke in a patient with Fahr's disease: Report of a rare case.Radiology case reports · 2025Article
- Rare Presentation of Homozygous SCase reports in genetics · 2025Article
- Case report: 10 years follow-up of psychosis due to Fahr's disease complicated by a left temporal stroke.Frontiers in psychiatry · 2023Article
- Ischemic stroke in a patient with Fahr's disease carrying biallelic mutations in theNeurosciences (Riyadh, Saudi Arabia) · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
backgroundIdiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge. CASE PRESENTATION: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure. Brain computed tomography showed symmetric calcifications in the bilateral basal ganglia, thalamus, cerebellar dentate nuclei, which were consistent with IBGC. Diffusion-weighted brain magnetic resonance imaging showed multiple small infarctions in the bilateral cerebral subcortical area. In the search for the cause of cerebral infarction, SPECT with acetazolamide challenge revealed heterogeneous impairment of cerebrovascular reactivity in the whole brain, despite the absence of evidence for steno-occlusive changes in proximal arteries.
conclusionCerebrovascular insufficiency due to the lack of elasticity caused by microvascular calcification might have been one of the pathophysiological features of IBGC in this case. Thus, vascular calcification may cause cerebrovascular disturbance and could lead to ischemic stroke in patients with IBGC.
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