ArticleThe Journal of international medical research2018
Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis.
Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- [Efficacy and safety ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Trial
- A multifunctional hyaluronic acid hydrogel with pH-responsive metformin release for accelerated healing of diabetic infected wounds.Materials today. Bio · 2026Article
- A comparative study of the established methods and evaluation of rat trauma models.Animal models and experimental medicine · 2025Article
- Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.Journal of translational medicine · 2025Article
- Nocardia rubra cell-wall skeleton mitigates whole abdominal irradiation-induced intestinal injury via regulating macrophage function.Burns & trauma · 2024Article
- [Regulatory effects of theZhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- The Nocardia Rubra Cell Wall Skeleton Regulates Macrophages and Promotes Wound Healing.Current issues in molecular biology · 2022Article
- Smart thermosensitive poloxamer hydrogels loaded with Nr-CWs for the treatment of diabetic wounds.PloS one · 2022Article
- Enhancing Natural Killer Cell-Mediated Cancer Immunotherapy by the Biological MacromoleculePathology oncology research : POR · 2022Article
- Rat epidermal stem cells promote the angiogenesis of full-thickness wounds.Stem cell research & therapy · 2020Article
- Nocardia Rubra Cell Wall Skeleton Up-Regulates T Cell Subsets and Inhibits PD-1/PD-L1 Pathway to Promote Local Immune Status of Patients With High-Risk Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia.Frontiers in immunology · 2020Article
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Authors and funding
8 authors.
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Abstract
Objective This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. Methods Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. Results N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. Conclusions N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing.
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