ArticleMechanisms of development2018
The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification.
Article in Mechanisms of development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- A novel mutation in the human RAX gene in patients with microphthalmia and coloboma: A case report and literature review.Medicine · 2026Review
- Establishment of human embryonic stem cell line expressing EGFP reporter driven by human RAX promoter for evaluation of retinal progenitor cell potency.In vitro cellular & developmental biology. Animal · 2026Article
- Development of Retinal Astroglia.Annual review of vision science · 2025Review
- Comparative Analysis of Convergent Jellyfish Eyes Reveals Extensive Differences in Expression of Vision-Related Genes.Ecology and evolution · 2025Article
- Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction.Investigative ophthalmology & visual science · 2025Article
- Itpka depletion implicates defects in anterior neural development ofFrontiers in cell and developmental biology · 2025Article
- NMNAT1 Is Essential for Human iPS Cell Differentiation to the Retinal Lineage.Investigative ophthalmology & visual science · 2024Article
- The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.Anatolian journal of cardiology · 2024Article
- Prdm15 acts upstream of Wnt4 signaling in anterior neural development ofFrontiers in cell and developmental biology · 2024Article
- The Ribosomal Protein L5 Functions DuringFrontiers in cell and developmental biology · 2022Article
- Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation.BMC biology · 2021Article
- The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration.International journal of medical sciences · 2020Review
- The Use of Induced Pluripotent Stem Cells as a Model for Developmental Eye Disorders.Frontiers in cellular neuroscience · 2020Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye development following optic vesicle formation. However, the functions of Rx in embryonic retinogenesis are still not fully understood. We investigated the function of Rx in the mouse neural retina using a conditional knockout where the Pax6α-Cre driver deletes Rx activity in early retinal progenitors. The deletion of Rx activity causes a loss of retinal lamination, a depletion of retinal progenitors, and a change in retinal cell fate in our conditional knockout model. The deletion of Rx leads to an absence of late-born retinal neurons (rods and bipolar cells) and Müller glia at postnatal ages, as well as a loss of the early-born cone photoreceptors. Decreased BrdU labeling in the Rx-deleted portion of the retina suggests a loss of retinal progenitors via early cell cycle exit, which likely prevents the formation of late-born cells. As early-born cells, cone photoreceptors should not be as affected by early cell cycle exit of retinal progenitors. However, embryonic cone photoreceptor labeling is also markedly reduced in Rx-deleted retinas. Together these data demonstrate the importance of Rx for retinal progenitor proliferation and a specific requirement of Rx for cone formation in mice.
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