ArticleHuman brain mapping2018
An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06010030 (A Randomized Clinical Trial of tDCS to Remediate Phonological Impairment in Aphasia), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial of tDCS to Remediate Phonological Impairment in Aphasia
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
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- Mapping and anatomo-surgical techniques for language preservation in brain tumours (Review).Experimental and therapeutic medicine · 2026Review
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Language remains strongly left-lateralized in older adults: A cross-sectional and longitudinal study.bioRxiv : the preprint server for biology · 2026Article
- The Georgetown Reading in Aging Neuroimaging Dataset (GRAND): Reading and multimodal MRI data in older adults.bioRxiv : the preprint server for biology · 2026Article
- Right hemisphere language network plasticity in aphasia.Brain : a journal of neurology · 2026Article
- Semantic and Phonological Brain Networks in Older Adults: A Systematic Scoping Review.Brain sciences · 2026Review
- When a Large Left Hemisphere Stroke is All Right for Language, Praxis, and Visual Attention: A Case Report.Neurology open access · 2025Article
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.medRxiv : the preprint server for health sciences · 2025Article
- Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia.Scientific reports · 2025Article
- Implications of shared motor and perceptual activations on the sensorimotor cortex for neuroprosthetic decoding.Journal of neural engineering · 2025Article
- An approach to measuring language-specific brain function in developmental language disorder.Acta psychologica · 2025Article
- Challenges and opportunities for advancing functional MRI in clinical practice.Brain : a journal of neurology · 2025Article
- Semantic Memory, Traumatic Brain Injury, and the Iceberg Effect: What Deficits May Lie Below the Surface?American journal of speech-language pathology · 2025Review
- Right Hemisphere Language Network Plasticity in Aphasia.medRxiv : the preprint server for health sciences · 2025Article
- Consensus recommendations for clinical functional MRI applied to language mapping.Aperture neuro · 2025Article
- Situating word deafness within aphasia recovery: A case report.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Functional Magnetic Resonance Imaging Activation During Unscripted Discourse in People With Poststroke Aphasia.Journal of speech, language, and hearing research : JSLHR · 2023Article
- A systematic review of neuroimaging approaches to mapping language in individuals.Journal of neurolinguistics · 2023Article
- ParAlg: A Paraphasia Algorithm for Multinomial Classification of Picture Naming Errors.Journal of speech, language, and hearing research : JSLHR · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Research on neuroplasticity in recovery from aphasia depends on the ability to identify language areas of the brain in individuals with aphasia. However, tasks commonly used to engage language processing in people with aphasia, such as narrative comprehension and picture naming, are limited in terms of reliability (test-retest reproducibility) and validity (identification of language regions, and not other regions). On the other hand, paradigms such as semantic decision that are effective in identifying language regions in people without aphasia can be prohibitively challenging for people with aphasia. This paper describes a new semantic matching paradigm that uses an adaptive staircase procedure to present individuals with stimuli that are challenging yet within their competence, so that language processing can be fully engaged in people with and without language impairments. The feasibility, reliability and validity of the adaptive semantic matching paradigm were investigated in sixteen individuals with chronic post-stroke aphasia and fourteen neurologically normal participants, in comparison to narrative comprehension and picture naming paradigms. All participants succeeded in learning and performing the semantic paradigm. Test-retest reproducibility of the semantic paradigm in people with aphasia was good (Dice coefficient = 0.66), and was superior to the other two paradigms. The semantic paradigm revealed known features of typical language organization (lateralization; frontal and temporal regions) more consistently in neurologically normal individuals than the other two paradigms, constituting evidence for validity. In sum, the adaptive semantic matching paradigm is a feasible, reliable and valid method for mapping language regions in people with aphasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.