ArticleJournal of child psychology and psychiatry, and allied disciplines2018
A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2022Trial
- Exploring Longitudinal Associations Among Error-Related Negativity, Perception of Interpersonal Events, and Internalizing Symptoms in Female Adolescents.Research on child and adolescent psychopathology · 2026Article
- Translating neurophysiological biomarkers into clinical tools: A psychometric blueprint illustrated with the error-related negativity.The American psychologist · 2025Review
- Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance.Biological psychiatry global open science · 2025Article
- Exploring the role of post-error processing in social anxiety across age.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Emotion Regulation Moderates the Prospective Association between ERN and Anxiety in Early Adolescence: An Age-Specific Moderation of Cognitive Reappraisal but not Expressive Suppression.Research on child and adolescent psychopathology · 2025Article
- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Multiple Adaptive Attention-Bias-Modification Programs to Alter Normative Increase in the Error-Related Negativity in Adolescents.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- The genetic architecture of youth anxiety: a study protocol.BMC psychiatry · 2024Article
- Multimodal study of the neural sources of error monitoring in adolescents and adults.Psychophysiology · 2023Article
- Towards a mechanistic understanding of the role of error monitoring and memory in social anxiety.bioRxiv : the preprint server for biology · 2023Article
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Rethinking the risk for depression using the RDoC: A psychophysiological perspective.Frontiers in psychology · 2023Review
- Effects of Parental Internalizing and Externalizing Behavior Problems on Children's Limbic Brain Structures-An MRI Study.Brain sciences · 2022Article
- Associations between lifetime stress exposure and the error-related negativity (ERN) differ based on stressor characteristics and exposure timing in young adults.Cognitive, affective & behavioral neuroscience · 2022Article
- Neural indices of performance monitoring are associated with daily emotional functioning in youth with anxiety disorders: An ERP and EMA study.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- The relationship between stressful life events and the error-related negativity in children and adolescents.Developmental cognitive neuroscience · 2022Article
- Maternal Error-Related Negativity Relationship With Offspring Error-Related Negativity and Negative Parenting Styles: A Novel Model of Internalizing Psychopathology Risk.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAn increased neural response to making mistakes has emerged as a potential biomarker of anxiety across development. The error-related negativity (ERN) is an event-related potential elicited when people make mistakes on simple laboratory-based reaction time tasks that has been associated with risk for anxiety. This study examined whether the ERN prospectively predicted the first onset of generalized anxiety disorder (GAD) over 1.5 years in adolescent girls.
methodsThe sample included 457 girls between the ages of 13.5 and 15.5 years, with no history of GAD. At baseline, the ERN was measured using a flankers task. Psychiatric history of the adolescent and biological parent was assessed with diagnostic interviews, and the adolescent completed a self-report questionnaire regarding anxiety symptoms. Approximately 1.5 years later, adolescents completed the same interview.
resultsAn increased neural response to errors at baseline predicted first-onset GAD over 1.5 years. The ERN was a significant predictor independent of other prominent risk factors, including baseline anxiety and depression symptoms and parental lifetime psychiatric history. Jointly the ERN and social anxiety symptoms provided the greatest power for predicting first-onset GAD.
conclusionsThis study provides evidence for the utility of the ERN as a biomarker of risk for GAD during a key developmental period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.