Evidence map›Paper›PMID 29665011›Full record

ArticleInternational journal of cancer2018

Colony stimulating factor 1 receptor blockade improves the efficacy of chemotherapy against human neuroblastoma in the absence of T lymphocytes.

Matthew W Webb, Jianping Sun, Michael A Sheard, Wei-Yao Liu, Hong-Wei Wu, Jeremy R Jackson, Jemily Malvar, Richard Sposto, Dylan Daniel, Robert C Seeger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 44 citations in OpenAlex.

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  11. Targeting the myeloid microenvironment in neuroblastoma.Journal of experimental & clinical cancer research : CR · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Matthew W WebbChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Jianping SunChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Michael A SheardChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Wei-Yao LiuChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Hong-Wei WuChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Jeremy R JacksonChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Jemily MalvarDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Richard SpostoChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.
Dylan DanielNovartis Institutes of BioMedical Research, Emeryville, CA, 94608.
Robert C SeegerChildren's Hospital Los Angeles and the Saban Research Institute, Los Angeles, CA 90027.ORCID 0000-0001-7242-0918
Children's Hospital of Los Angeles · USUniversity of Southern California · USNovartis (United States) · US

Funding

Vascular endothelial cell integrins in angiogenesisP01CA081403 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI SEEGER, ROBERT CHARLES · 2000 to 2014
$28.5M
Molecular Diagnostics for Risk Stratification and Monitoring of NeuroblastomaR01CA182633 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI ASGHARZADEH, SHAHAB, SEEGER, ROBERT CHARLES · 2014 to 2016
$2.0M
NCI NIH HHS P01 CA081403NCI NIH HHS R01 CA182633
6 · The paper itself

Abstract

Tumor-associated macrophages can promote growth of cancers. In neuroblastoma, tumor-associated macrophages have greater frequency in metastatic versus loco-regional tumors, and higher expression of genes associated with macrophages helps to predict poor prognosis in the 60% of high-risk patients who have MYCN-non-amplified disease. The contribution of cytotoxic T-lymphocytes to anti-neuroblastoma immune responses may be limited by low MHC class I expression and low exonic mutation frequency. Therefore, we modelled human neuroblastoma in T-cell deficient mice to examine whether depletion of monocytes/macrophages from the neuroblastoma microenvironment by blockade of CSF-1R can improve the response to chemotherapy. In vitro, CSF-1 was released by neuroblastoma cells, and topotecan increased this release. In vivo, neuroblastomas formed by subcutaneous co-injection of human neuroblastoma cells and human monocytes into immunodeficient NOD/SCID mice had fewer human CD14

Indexed as

Drug Resistance, NeoplasmAnimalsAntineoplastic AgentsApoptosisBenzothiazolesBiomarkers, TumorCell ProliferationCells, CulturedDisease Models, AnimalHumansMacrophagesMiceMice, Inbred NODMice, SCIDMonocytesNeuroblastoma4-(2-(2-hydroxycyclohexylamino)benzothiazol-6-yloxy)pyridine-2-carboxylic acid methylamideAntineoplastic AgentsBenzothiazolesBiomarkers, TumorCSF1R protein, humanPicolinic AcidsReceptor, Macrophage Colony-Stimulating FactorReceptors, Granulocyte-Macrophage Colony-Stimulating Factor5A1BLZ945MCS110neuroblastomatumor-associated macrophage

Identifiers

PMID29665011
PMCPMC6105468
OpenAlexW2802364378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.