Evidence map›Paper›PMID 29664996›Full record

ArticleThe British journal of surgery2018

Prognostic impact of perihepatic lymph node metastases in patients with resectable colorectal liver metastases.

M Okuno, C Goumard, T Mizuno, S Kopetz, K Omichi, C-W D Tzeng, Y S Chun, J E Lee, J-N Vauthey, C Conrad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M OkunoDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
C GoumardDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
T MizunoDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
S KopetzDepartment of Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
K OmichiDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
C-W D TzengDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Y S ChunDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
J E LeeDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
J-N VautheyDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-4921-5427
C ConradDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9912-4545
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672NCI NIH HHS P30CA016672NIH HHS P30CA016672
6 · The paper itself

Abstract

backgroundAlthough perihepatic lymph node metastases (PLNMs) are known to be a poor prognosticator for patients with colorectal liver metastases (CRLMs), optimal management remains unclear. This study aimed to determine the risk factors for PLNMs, and the survival impact of their number and location in patients with resectable CRLMs.

methodsData on patients with CRLM who underwent hepatectomy during 2003-2014 were analysed retrospectively. Recurrence-free (RFS) and overall (OS) survival were calculated according to presence, number and location of PLNMs. Risk factors for PLNM were evaluated by logistic regression analysis.

resultsOf 1485 patients, 174 underwent lymphadenectomy, and 54 (31·0 per cent) had PLNM. Ten patients (5·7 per cent) who had lymphadenectomy and 176 (13·4 per cent) who did not underwent repeat hepatectomy. Survival of patients with PLNM was significantly poorer than that of patients without (RFS: 5·3 versus 13·8 months, P < 0·001; OS: 20·5 versus 71·3 months; P < 0·001). Median OS was significantly better in patients with para-aortic versus hepatoduodenal ligament PLNMs (58·2 versus 15·5 months; P = 0·011). Patients with three or more PLNMs had significantly worse median OS than those with one or two (16·3 versus 25·4 months; P = 0·039). The presence of primary tumour lymph node metastases (odds ratio 2·35; P = 0·037) and intrahepatic recurrence requiring repeat hepatectomy (odds ratio 5·61; P = 0·012) were significant risk factors for PLNM on multivariable analysis.

conclusionPatients undergoing repeat hepatectomy and those with primary tumour lymph node metastases are at significant risk of PLNM. Although PLNM is a poor prognostic factor independent of perihepatic lymph node station, patients with one or two PLNMs have a more favourable outcome than those with more PLNMs.

Indexed as

HepatectomyNeoplasm StagingAgedBiopsyColorectal NeoplasmsFemaleFollow-Up StudiesHumansLiver NeoplasmsLymphatic MetastasisMalePrognosisProspective StudiesSurvival RateTexasTomography, X-Ray Computed

Identifiers

PMID29664996
PMCPMC7938855
OpenAlexW2801461559

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.