ArticlePloS one2018
Combined experimental and computational characterization of crosslinked collagen-based hydrogels.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 85 citations in OpenAlex.
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- Tumor Organoids Grown in Mixed-Composition Hydrogels Recapitulate the Plasticity of Pancreatic Cancers.Gels (Basel, Switzerland) · 2025Article
- Quantitative characterization of the 3D self-organization of PDAC tumor spheroids reveals cell type and matrix dependence through advanced microscopy analysis.APL bioengineering · 2025Article
- Dense Collagen I as a Biomimetic Material to Track Matrix Remodelling in Renal Carcinomas.ACS omega · 2024Article
- Polydopamine Interfacial Coating for Stable Tumor-on-a-Chip Models: Application for Pancreatic Ductal Adenocarcinoma.Biomacromolecules · 2024Article
- Morphological Stability for in silico Models of Avascular Tumors.Bulletin of mathematical biology · 2024Article
- 3D Artificial Skin Platform for Investigating Pregnancy-Related Skin Pigmentation.Micromachines · 2024Article
- A human initial lymphatic chip reveals distinct mechanisms of primary lymphatic valve dysfunction in acute and chronic inflammation.Lab on a chip · 2023Article
- Hydrocolloids of Egg White and Gelatin as a Platform for Hydrogel-Based Tissue Engineering.Gels (Basel, Switzerland) · 2023Article
- Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth.Biomacromolecules · 2023Article
- Adipose-Derived Stem Cells in Reinforced Collagen Gel: A Comparison between Two Approaches to Differentiation towards Smooth Muscle Cells.International journal of molecular sciences · 2023Article
- Integration of reconfigurable microchannels into aligned three-dimensional neural networks for spatially controllable neuromodulation.Science advances · 2023Article
- A bone-on-a-chip collagen hydrogel-based model using pre-differentiated adipose-derived stem cells for personalized bone tissue engineering.Journal of biomedical materials research. Part A · 2023Article
- Encapsulation of MSCs and GDNF in an Injectable Nanoreinforced Supramolecular Hydrogel for Brain Tissue Engineering.Biomacromolecules · 2022Article
- Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.Nature communications · 2022Article
- Application of Injectable, Crosslinked, Fibrin-Containing Hyaluronic Acid Scaffolds for In Vivo Remodeling.Journal of functional biomaterials · 2022Article
- Tissue Engineering Techniques for Induced Pluripotent Stem Cell Derived Three-Dimensional Cardiac Constructs.Tissue engineering. Part B, Reviews · 2022Review
- A 3D multi-agent-based model for lumen morphogenesis: the role of the biophysical properties of the extracellular matrix.Engineering with computers · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen hydrogels are widely used for in-vitro experiments and tissue engineering applications. Their use has been extended due to their biocompatibility with cells and their capacity to mimic biological tissues; nevertheless their mechanical properties are not always optimal for these purposes. Hydrogels are formed by a network of polymer filaments embedded on an aqueous substrate and their mechanical properties are mainly defined by the filament network architecture and the individual filament properties. To increase properties of native collagen, such as stiffness or strain-stiffening, these networks can be modified by adding crosslinking agents that alter the network architecture, increasing the unions between filaments. In this work, we have investigated the effect of one crosslinking agent, transglutaminase, in collagen hydrogels with varying collagen concentration. We have observed a linear dependency of the gel rigidity on the collagen concentration. Moreover, the addition of transglutaminase has induced an earlier strain-stiffening of the collagen gels. In addition, to better understand the mechanical implications of collagen concentration and crosslinkers inclusion, we have adapted an existing computational model, based on the worm-like chain model (WLC), to reproduce the mechanical behavior of the collagen gels. With this model we can estimate the parameters of the biopolymer networks without more sophisticated techniques, such as image processing or network reconstruction, or, inversely, predict the mechanical properties of a defined collagen network.
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