ArticleEmerging infectious diseases2018
Antimicrobial Resistance in Invasive Bacterial Infections in Hospitalized Children, Cambodia, 2007-2016.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 61 citations in OpenAlex.
- Epidemiological trends of multidrug-resistant organisms in a tertiary-care pediatric hospital, 2017-2023.Italian journal of pediatrics · 2026Article
- Neonatal Infections Caused by Multidrug-Resistant Bacteria: An Analysis of Prevalence, Risk Factors, and Therapeutic Implications-A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Combating antimicrobial resistance in Asia: A comprehensive review of strategic action plans, policies, and the role of the WHO.Saudi medical journal · 2025Review
- Prevalence and characterization of third-generation cephalosporin, carbapenem and colistin-resistant Enterobacterales isolated from clinical samples in Cambodia.New microbes and new infections · 2025Article
- A comprehensive analysis of antimicrobial resistance of clinicalJAC-antimicrobial resistance · 2025Article
- AmpC β-lactamases detected in Southeast AsianJAC-antimicrobial resistance · 2024Article
- Antimicrobial susceptibility profiles of invasive bacterial infections among children from low- and middle-income countries in the Western Pacific Region (WPRO) - a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2024Article
- Antimicrobial resistance among common bacterial pathogens in Indonesia: a systematic review.The Lancet regional health. Southeast Asia · 2024Article
- The causes of bacterial bloodstream infections and antimicrobial resistance patterns in children attending a secondary care hospital in Bhaktapur, Nepal, 2017-2022: a retrospective study.JAC-antimicrobial resistance · 2024Article
- Infections transmitted via the faecal-oral route: a simple score for a global risk map.Journal of travel medicine · 2023Article
- Methicillin resistantTropical doctor · 2023Article
- Detection of volatile organic compounds in headspace ofFrontiers in pediatrics · 2023Article
- Microbiological profile of bloodstream infections and antimicrobial resistance patterns at a tertiary referral hospital in Amazon, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Observational
- The barriers and facilitators of implementing a national laboratory-based AMR surveillance system in Cambodia: key informants' perspectives and assessments of microbiology laboratories.Frontiers in public health · 2023Article
- Detection of maternal transmission of resistant Gram-negative bacteria in a Cambodian hospital setting.Frontiers in microbiology · 2023Article
- Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- Gastrointestinal Carriage of Antimicrobial Resistance in School-Aged Children in Three Municipalities of Timor-Leste.Antibiotics (Basel, Switzerland) · 2022Article
- Impact of delayed processing of positive blood cultures on organism detection: a prospective multi-centre study.BMC infectious diseases · 2022Article
- Early-onset neonatal sepsis and antibiotic use in Indonesia: a descriptive, cross-sectional study.BMC public health · 2022Article
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Authors and funding
17 authors at 7 institutions in 5 countries.
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Abstract
To determine trends, mortality rates, and costs of antimicrobial resistance in invasive bacterial infections in hospitalized children, we analyzed data from Angkor Hospital for Children, Siem Reap, Cambodia, for 2007-2016. A total of 39,050 cultures yielded 1,341 target pathogens. Resistance rates were high; 82% each of Escherichia coli and Klebsiella pneumoniae isolates were multidrug resistant. Hospital-acquired isolates were more often resistant than community-acquired isolates; resistance trends over time were heterogeneous. K. pneumoniae isolates from neonates were more likely than those from nonneonates to be resistant to ampicillin-gentamicin and third-generation cephalosporins. In patients with community-acquired gram-negative bacteremia, third-generation cephalosporin resistance was associated with increased mortality rates, increased intensive care unit admissions, and 2.26-fold increased healthcare costs among survivors. High antimicrobial resistance in this setting is a threat to human life and the economy. In similar low-resource settings, our methods could be reproduced as a robust surveillance model for antimicrobial resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.