Evidence map›Paper›PMID 29664322›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Substitution of venous for arterial blood sampling in the determination of regional rates of cerebral protein synthesis with L-[1-

Giampaolo Tomasi, Mattia Veronese, Alessandra Bertoldo, Carolyn B Smith, Kathleen C Schmidt

Open access · bronzeAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Evaluating image-derived input functions for cerebral [Frontiers in nuclear medicine · 2025
    Article
  2. Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  3. Supervised clustering for TSPO PET imaging.European journal of nuclear medicine and molecular imaging · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Giampaolo Tomasi1 Section on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, MD, USA.
Mattia Veronese2 Department of Neuroimaging, IoPPN, King's College London, London, UK.
Alessandra Bertoldo3 Department of Information Engineering, University of Padova, Padova, Italy.
Carolyn B Smith1 Section on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, MD, USA.
Kathleen C Schmidt1 Section on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, Bethesda, MD, USA.
National Institute of Mental Health · USKing's College London · GBUniversity of Padua · IT

Funding

Mathematical and Statistical Analysis Techniques for in Vivo Imaging StudiesZIAMH002935 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BEEBE SMITH, CAROLYN · 2012 to 2019
$1.4M
Department of HealthWellcome Trust
6 · The paper itself

Abstract

We developed and validated a method to estimate input functions for determination of regional rates of cerebral protein synthesis (rCPS) with L-[1-

Indexed as

Protein BiosynthesisAdolescentAdultBrainCarbon RadioisotopesFemaleHumansLeucineMalePositron-Emission TomographyYoung AdultCarbon RadioisotopesLeucineBrainleucinepositron emission tomographyprotein synthesisvenous blood sampling

Identifiers

PMID29664322
PMCPMC6727135
OpenAlexW2800966951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.