Evidence map›Paper›PMID 29664174›Full record

ArticleJournal of cellular and molecular medicine2018

Up-regulated Cx43 phosphorylation at Ser368 prolongs QRS duration in myocarditis.

Chunlian Zhong, He Chang, Yang Wu, Li Zhou, Yan Wang, Mingyan Wang, Peng Wu, Zhi Qi, Jun Zou

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Innate and adaptive immunity in acute myocarditis.International journal of cardiology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. p38 MAPK Pathway in the Heart: New Insights in Health and Disease.International journal of molecular sciences · 2020
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chunlian ZhongDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
He ChangDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Yang WuDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Li ZhouDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Yan WangDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Mingyan WangDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Peng WuDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Zhi QiDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.ORCID 0000-0002-6580-4013
Jun ZouDepartment of Basic Medical Sciences, Medical College of Xiamen University, Xiamen, China.
Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolongation of QRS duration in electrocardiogram is one of the risk factors for morbidity and mortality in many kinds of cardiac diseases. However, its molecular mechanism is unknown. In this study, utilizing experimental autoimmune myocarditis (EAM) as a disease model, we show that the prolongation of QRS duration is accompanied by elevated phosphorylation of connexin 43 (Cx43) at Ser368 (p

Indexed as

ElectrocardiographyAnimalsCell CommunicationConnexin 43Disease Models, AnimalHeartInterleukin-1betaMaleMAP Kinase Signaling SystemMyocarditisMyocardiumOrgan Culture TechniquesPhosphorylationRats, Inbred LewSerineUp-RegulationConnexin 43Gja1 protein, ratIL1B protein, ratInterleukin-1betaSerineconnexin 43experimental autoimmune myocarditisIL-1βp38 MAPKQRS duration

Identifiers

PMID29664174
PMCPMC6010859
OpenAlexW2799511449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.