ArticleChinese medical journal2018
Association between Perceived Stressfulness of Stressful Life Events and the Suicidal Risk in Chinese Patients with Major Depressive Disorder.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02023567 (The Establishment of the Objective Diagnostic Markers and Personalized Medical Intervention in Patients With Major Depressive Disorders), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Establishment of the Objective Diagnostic Markers and Personalized Medical Intervention in Patients With Major Depressive Disorders (MDD)
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization.European archives of psychiatry and clinical neuroscience · 2022Trial
- Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia.Translational psychiatry · 2025Article
- Three-dimensional facial features of suicide risk in females with depression.Frontiers in psychiatry · 2025Article
- Using Machine Learning and the HAMD-24 Scale to Predict Suicide Ideation in Depressed Patients.Psychology research and behavior management · 2025Article
- CD4Neurobiology of stress · 2024Article
- Longitudinal Association between Stressful Life Events and Suicidal Ideation in Adults with Major Depression Disorder: The Mediating Effects of Insomnia Symptoms.Behavioral sciences (Basel, Switzerland) · 2024Article
- Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden.BMC psychiatry · 2024Article
- Negative life events and depression by gender in the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil).Clinics (Sao Paulo, Brazil) · 2024Article
- Article
- The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder.BMC psychiatry · 2023Article
- Clinical symptoms, thyroid dysfunction, and metabolic disturbances in first-episode drug-naïve major depressive disorder patients with suicide attempts: A network perspective.Frontiers in endocrinology · 2023Article
- Stressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study.Frontiers in public health · 2022Article
- Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study.BMC psychiatry · 2020Article
- Article
- Determinants of Suicide-related Ideation in Late Life Depression: Associations with Perceived Stress.Clinical gerontologistArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese patients with MDD.
methodsIn total, 1029 patients with MDD were included from nine psychiatric hospitals to evaluate the impact of SLEs on suicidal risk. Patients fulfilling the Mini-International Neuropsychiatric Interview (MINI) criteria for MDD were included in the study. Patients were excluded if they had lifetime or current diagnoses of psychotic disorder, bipolar disorder, and alcohol or substance dependence. Depressive symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17). The suicidal risk of MDD patients was determined by the suicide risk module of MINI. SLEs were assessed by the Life Events Scale.
resultsNo gender difference was found for suicidal risk in MDD patients. Patients with suicidal risk had younger ages, lower education levels, more drinking behavior, and lower marriage rate, and fewer people had child and more severe depressive symptoms than nonsuicidal risk group. High-level perceived stressfulness (HPS) and number of SLEs that patients were exposed to were significantly greater in patients with suicidal risk than patients without. In multivariate logistic analysis, HPS of SLEs (odds ratio [OR] = 1.54, 95% confidence interval [CI]: 1.16-2.05, P = 0.003) and depressive symptoms (OR = 1.08, 95% CI: 1.05-1.11, P < 0.001) were associated with suicidal risk even after adjustment of gender, age, marriage, drinking behavior, and childless.
conclusionsHPS of SLEs is associated with suicide risk in Chinese patients with MDD. Further suicide prevention programs targeting this risk factor are needed.
trial registrationClinicalTrials.gov: NCT02023567; https://clinicaltrials.gov/ct2/show/NCT02023567?term=NCT02023567&rank=1.
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