Evidence map›Paper›PMID 29664006›Full record

ArticleeLife2018

A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in

Wei Jiang, Yuehua Wei, Yong Long, Arthur Owen, Bingying Wang, Xuebing Wu, Shuo Luo, Yongjun Dang, Dengke K Ma

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 50 citations in OpenAlex.

  1. Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  5. Suppressing APOE4-induced mortality and cellular damage by targeting VHL.bioRxiv : the preprint server for biology · 2024
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  13. MultiplebioRxiv : the preprint server for biology · 2023
    Article
  14. Article
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  18. [Cold stress reduces lifespan and mobility ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Wei Jiang *Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.ORCID 0000-0001-7615-0900
Yuehua Wei *Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.
Yong Long *Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.
Arthur OwenDepartment of Molecular Cell Biology, University of California, Berkeley, Berkeley, United States.
Bingying WangCardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.
Xuebing WuWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0003-0369-5269
Shuo LuoWhitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, United States.
Yongjun DangKey Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Fudan University, Shanghai, China.ORCID 0000-0001-7237-1132
Dengke K MaCardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-5619-7485
University of California, San Francisco · USShanghai Medical College of Fudan University · CNWhitehead Institute for Biomedical Research · USUniversity of California, Berkeley · US

Funding

Signals from the reproductive system that regulate aging in C. elegansR01AG032435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, HAO · 2009 to 2018
$3.3M
Dissecting a Novel Genetic Pathway for Fatty Acid Desaturation and Temperature AdaptationR01GM117461 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, DENGKE · 2016 to 2020
$1.6M
Control of Anoxia-Reoxygenation Responses by the O2-sensing Enzyme EGL-9 PathwayR00HL116654 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, DENGKE · 2015 to 2017
$744k
NHLBI NIH HHS R00 HL116654NHLBI NIH HHS R00HL116654NIA NIH HHS R01 AG032435NIA NIH HHS R01AG032435NIGMS NIH HHS R01 GM117461NIGMS NIH HHS R01GM117461
6 · The paper itself

Abstract

How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From

Indexed as

Cold TemperatureGene Expression RegulationStress, PhysiologicalAnimalsBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Regulatory NetworksBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegans Proteinszip-10 protein, C elegansbZIP transcription factorC. elegansC. elegans screenchromosomesforward geneticsgene expressionhypothermiaISY1 or ISY-1ZIP-10

Identifiers

PMID29664006
PMCPMC5903861
OpenAlexW2951000902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.